Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol diet Jose O. Leite, Ryan DeOgburn, Joseph.

Slides:

Advertisements

Similar presentations

Date of download: 5/28/2016 Copyright © The American College of Cardiology. All rights reserved. From: A Novel Inhibitory Effect of Naloxone on Macrophage.

Advertisements

The Survival Kit: Software to analyze survival data including possibly correlated random effects G. Mészáros, J. Sölkner, V. Ducrocq Computer Methods and.

Effects of plant stanol esters on serum cholesterol concentrations, relative markers of cholesterol metabolism and endothelial function in type 1 diabetes

Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor.

Blood leukocyte count is a risk factor for intima-media thickening and subclinical carotid atherosclerosis in middle-aged men Antti Loimaala, Riikka.

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6- year follow-up. The cardiovascular risk in Young Finns study

Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice Rien van Haperen, Caroline Cheng, Barend.

High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids Sonia C. Garcia Caraballo, Tine M. Comhair,

Plasma levels of trimethylamine-N-oxide are confounded by impaired kidney function and poor metabolic control Daniel M. Mueller, Martina Allenspach,

Transglutaminase activity regulates atherosclerotic plaque composition at locations exposed to oscillatory shear stress Hanke L. Matlung, Annette E.

Influence of apolipoprotein E, age and aortic site on calcium phosphate induced abdominal aortic aneurysm in mice Yutang Wang, Smriti M. Krishna, Joseph.

Association between sleep apnea, snoring, incident cardiovascular events and all-cause mortality in an adult population: MESA Joseph Yeboah, Susan Redline,

A longitudinal analysis on associations of adiponectin levels with metabolic syndrome and carotid artery intima-media thickness. The Cardiovascular Risk.

Optimal pharmacologic approach to patients with hypertriglyceridemia and low high- density lipoprotein-cholesterol: Randomized comparison of fenofibrate.

Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: The Cardiovascular Risk in Young Finns Study David P. Burgner,

DOI: /j.atherosclerosis

Arterial pulse wave velocity in relation to carotid intima-media thickness, brachial flow- mediated dilation and carotid artery distensibility: The Cardiovascular.

Talin and vinculin are downregulated in atherosclerotic plaque; Tampere Vascular Study Magdaléna von Essen, Rolle Rahikainen, Niku Oksala, Emma Raitoharju,

Anti-oxidant and anti-atherogenic properties of liposomal glutathione: Studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice Rosenblat.

LDL-cholesterol lowering increases plasma apelin in isolated hypercholesterolemia Ilker Tasci, Gokhan Erdem, Gokhan Ozgur, Serkan Tapan, Teoman Dogru,

High-normal fasting blood glucose in non-diabetic range is associated with increased coronary artery calcium burden in asymptomatic men Khurram Nasir,

DOI: /j.atherosclerosis

Maros Ferencik, Yiannis S. Chatzizisis Atherosclerosis

Liquid fructose supplementation in LDL-R−/− mice fed a western-type diet enhances lipid burden and atherosclerosis despite identical calorie consumption

Increased amount of bone marrow-derived smooth muscle-like cells and accelerated atherosclerosis in diabetic apoE-deficient mice J.O. Fledderus, O. van.

Adult dyslipidemia prediction is improved by repeated measurements in childhood and young adulthood. The Cardiovascular Risk in Young Finns Study Joel.

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti- inflammatory type II macrophages and upregulation of beta-2 integrins in.

Improved cardiovascular outcomes following temporal advances in lipid-lowering therapy in a genetically-characterised cohort of familial hypercholesterolaemia.

DOI: /j.atherosclerosis

Increased atherosclerotic lesion area in apoE deficient mice overexpressing bovine growth hormone Irene J. Andersson, Anna Ljungberg, Lennart Svensson,

Erkan Söğüt, Hasan Kadı, Metin Karayakalı, Cuma Mertoğlu

Effect of age, gender and cardiovascular risk factors on carotid distensibility during 6- year follow-up. The cardiovascular risk in Young Finns study

Plasma levels of granzyme B are increased in patients with lipid-rich carotid plaques as determined by echogenicity Mona Skjelland, Annika E. Michelsen,

Plasma apoAV levels are markedly elevated in severe hypertriglyceridemia and positively correlated with the APOA5 S19W polymorphism Peter Henneman, Frank.

Prevention of atherosclerosis by the mTOR inhibitor everolimus in LDLR−/− mice despite severe hypercholesterolemia Marc A. Mueller, Frank Beutner, Daniel.

Very high childhood obesity prevalence and low adherence rates to the Mediterranean diet in Greek children: The GRECO study Paul Farajian, Grigoris Risvas,

Significant abnormalities of the HDL phosphosphingolipidome in type 1 diabetes despite normal HDL cholesterol concentration Damien Denimal, Jean-Paul.

Change in Lipid Profile in Celiac Disease: Beneficial Effect of Gluten-Free Diet Pardeep Brar, MD, Grace Y. Kwon, MD, Steve Holleran, BA, Diane Bai, MD,

Iron, inflammation and atherosclerosis risk in men vs

Omega-6 polyunsaturated fatty acids prevent atherosclerosis development in LDLr-KO mice, in spite of displaying a pro-inflammatory profile similar to.

The relation of serum gamma-glutamyl transferase levels with coronary lesion complexity and long-term outcome in patients with stable coronary artery.

The role of lymphatic vessels in the heart

Volume 18, Issue 2, Pages (April 2011)

Hypoglycemic and hypolipidemic effect and antioxidant activity of chronic epigallocatechin-gallate in streptozotocin-diabetic rats Mehrdad Roghani, Tourandokht.

Volume 18, Issue 2, Pages (April 2011)

Brachial artery occlusion secondary to hypereosinophilic syndrome

Volume 44, Issue 4, Pages (April 2006)

Think Again About Cholesterol Survey

Marina Cuchel, Dirk J. Blom, Maurizio R. Averna

Volume 14, Issue 10, Pages (March 2016)

Validation of semiautomated and locally resolved aortic wall thickness measurements from computed tomography Eric K. Shang, MD, Eric Lai, BS, Alison.

Volume 11, Issue 2, Pages (October 2004)

Volume 16, Issue 1, Pages 9-13 (June 2009)

Mark F Berry, MD, Y.Joseph Woo, MD The Annals of Thoracic Surgery

Volume 13, Issue 5, Pages (May 2011)

Antihyperglycemic and antihyperlipidemic effect of Rumex patientia seed preparation in streptozotocin-diabetic rats Reza Sedaghat, Mehrdad Roghani, Maedeh.

Volume 9, Issue 5, Pages (May 2009)

Extra-anatomical Aortobifemoral Bypass for Juxtarenal Aortic Occlusion

Volume 10, Issue 1, Pages (July 2009)

Sokunthea Peou, PharmD, Brittany Milliard-Hasting, MD, Sachin A

PC194 Ectopic Expression of Proprotein Convertase Subtilisin Kexin Type 9 by Smooth Muscular Cells Contributes to Aortic Dissection Yasunori IIda, Hiroki.

Skin cancer epidemic in a wireless world

Pitavastatin and HDL: Effects on plasma levels and function(s)

Pheochromocytoma Presenting as Fever of Unknown Origin

Joseph J. Piotrowski, MD, Glenn C. Hunter, MD, Cleamond D

III. Treating dyslipidemias

Seizures following subclavian-carotid bypass

Individual lipid measures for high-carbohydrate (n=10) and low-carbohydrate (n=10) ultra-endurance athletes. Individual lipid measures for high-carbohydrate.

In This Issue Cell Volume 145, Issue 3, (April 2011)

Presentation transcript:

Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol diet Jose O. Leite, Ryan DeOgburn, Joseph Ratliff, Randy Su, Joan A. Smyth, Jeff S. Volek, Mary M. McGrane, Alan Dardik, Maria Luz Fernandez Atherosclerosis Volume 209, Issue 2, Pages 442-448 (April 2010) DOI: 10.1016/j.atherosclerosis.2009.10.005 Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Correlations between total cholesterol (TC) and LDL cholesterol (panel A); LDL cholesterol (LDL-C) and HDL cholesterol (HDL-C) (panel B); VLDL cholesterol (VLDL-C) and triglycerides (TG) (panel C) and aortic total cholesterol and LDL cholesterol (LDL-C) (panel D). Atherosclerosis 2010 209, 442-448DOI: (10.1016/j.atherosclerosis.2009.10.005) Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Oxidized LDL in plasma (panel A) and in aorta (panel B) for guinea pigs the LFD or LCD diets. Correlation between aortic concentrations of oxidized LDL and accumulation of cholesterol in aorta for LFD group (panel C) and LCD group (panel D). Atherosclerosis 2010 209, 442-448DOI: (10.1016/j.atherosclerosis.2009.10.005) Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 IHC for TNF-α of the aortic sinus of guinea pigs fed the LFD (panel A, 40× magnification, panel B 400× magnification) or LCD (panel C, 40× magnification, panel D 400× magnification). Atherosclerosis 2010 209, 442-448DOI: (10.1016/j.atherosclerosis.2009.10.005) Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Hematoxylin and eosin staining of the aortic sinus of guinea pigs fed the LCD (panel A, 40× magnification, panel C 400× magnification) or LFD (panel B, 40× magnification, panel D 400× magnification). Arrows point to the lipid-laden cells. Atherosclerosis 2010 209, 442-448DOI: (10.1016/j.atherosclerosis.2009.10.005) Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 Image processing of the cholesterol staining of left carotid in both groups and quantification of the blue-green stain—LCD: left carotid at 400× magnification (panel A). LFD: left carotid at 400× magnification (panel B). The arrows point to the positive staining for cholesterol. Panel C: statistical analysis of the proportion of the positive blue-green staining to the arterial area in the picture of the left carotid. Atherosclerosis 2010 209, 442-448DOI: (10.1016/j.atherosclerosis.2009.10.005) Copyright © 2009 Elsevier Ireland Ltd Terms and Conditions