Longitudinal effects of aging on date-adjusted testosterone (T) and free testosterone index (free T index). Linear segment plots for total T and free T.

Slides:

Advertisements

Similar presentations

Girl, 13-4/12 years old, with constitutional delay in growth and puberty. History revealed a normal growth rate but short stature at all ages. Physical.

Advertisements

18 F-deoxyglucose (18FDG) PET/CT fusion scan

(Modified from Hanley NA, Arlt W

Stage P1: Preadolescent; the vellus over the area is no further developed than that over the anterior abdominal wall (ie, no pubic hair). Stage P2: Sparse.

****Suppression of the serum TSH with levothyroxine has been shown to be of more benefit in patients with higher stages of disease. In older patients with.

Hypogonadism in aging men

(Adapted, with permission, from Fagin JA

Comparison of disease progression in patients with colorectal cancer receiving vitamin C versus placebo. (Reproduced, with permission, from Moertel CG,

(The data are from Southard RN, et al

Risk designation of full-term and near-term newborns based on their hour-specific bilirubin values. (Reproduced, with permission, from Bhutani VK et al:

(Reproduced with permission from Jemal A, et al: Cancer statistics, CA Cancer J Clin 58:71, 2008.) Source: Chapter 17. The Breast, Schwartz's Principles.

Hands of a patient with pseudohypoparathyroidism

(Reproduced, with permission, from Findling JW, et al

A. Relationship between serum-free thyroxine by dialysis (FT4) ng/dL and log10 TSH in euthyroid, hyperthyroid, hypothyroid, and T4-suppressed euthyroid.

This patient has a total hip bone mineral density (BMD) of 0

(Reproduced, with permission, from Gougeon A

(Reproduced, with permission, from Findling JW

This patient has a lumbar spine (L1-L4) bone mineral density (BMD) of g/cm2 (cross on the reference database graph) measured by dual-energy x-ray.

Fig. 1. Mean BMI and BMI Z-score (se) of the children with AA, TA, and TT genotypes in rs of the FTO gene. The P values are for the additive model.

Fig. 1. Correlation of TSH with TC, LDL-C, HDL-C, and TG.

Hypothetical distribution of test results for healthy and diseased individuals. The position of the "cutoff point" between "normal" and "abnormal" (or.

Oral contraceptive pill hormonal components

Oral contraceptive pill hormonal components

Animal model for Graves disease

Serum medroxyprogesterone acetate (MPA) and estradiol levels following Lunelle injection. (Reproduced with permission from Rahimy MH, Ryan KK, Hopkins.

Nat Clin Pract Endocrinol Metab 3: 279–289 doi: /ncpendmet0447

Nat. Rev. Endocrinol. doi: /nrendo

Schematic representation of the autonomic nervous system

Comparative serum steroid (CSS) levels of norelgestromin (NGMN) and ethinyl estradiol (EE) following patch administration. (Reproduced with permission.

Fig. 1. Flow of subjects through different phases of the study.

Biosynthesis and metabolism of testosterone

The stages of Reproductive Aging Workshop +10 staging system for reproductive aging in women. (Reproduced with permission from Harlow SD, Gass M, Hall.

(Reproduced, with permission, from Langman J, Sadler TW

Model of the interaction of T3 with the T3 receptor

A. Magnified x-ray of index finger on fine-grain industrial film showing classic subperiosteal resorption in a patient with severe primary hyperparathyroidism.

Illustration of ways regression lines can differ

One theory of the pathogenesis of Graves disease

Proposed pathogenesis of Graves disease

A 48-year-old man had a 7-year history of hypertension that was not optimally controlled on four antihypertensive drugs (β-adrenergic blocker, peripheral.

Diagrammatic representation of the mechanism of action of testosterone on target cells. Testosterone (T) circulates in association with sex hormone–binding.

Potential hormonal mediators of amenorrhea

As is shown, men treated by radical prostatectomy had a better adjusted survival rate than men without prostate cancer suggesting selection biases for.

Kaplan-Meier survival for adult heart transplants performed between January 1982 and June 2006 by era. All comparisons are significant at p < (Reproduced.

Prostate cancer mortality as a factor of Gleason score and age at diagnosis in men managed conservatively. (Adapted, with permission, from Albertsen PC.

Figure 1. Total (A) and free (B) T, estradiol (C), and SHBG (D) levels at baseline and during treatment. From: Testosterone Treatment and Sexual Function.

Screening for MEN1-associated neoplasia

Adjusting probabilities with new information and treatment thresholds

(Modified from Conlin PR, et al

(Adapted and reprinted with permission, from Hughes JM et al: Effect of lung volume on the distribution of pulmonary blood flow in man. Respir Physiol.

Schema of the two zinc fingers, together with coordinated zinc ion, which make up the DNA-binding domain of the glucocorticoid receptor (amino acids are.

Decision tree for ulcerative colitis

Adapted with permission from Hsia, J et al

Adult basic life support health care provider algorithm

MRI contrast-enhancement and progression of X-ALD

FIG. 1 Odds ratios (95% CIs) of metabolic syndrome and individual components calculated for clinical measures of periodontal disease (A and B). For gingival.

(Copyright © 1977 American Diabetes Association. Marliss EB et al

Relationship of oxygenation, as reflected in the ratio of the arterial and alveolar oxygen tensions (a/A ratio), to the mean airway pressure (mPaw) applied.

Hypogonadism in aging men

Patient with mild ophthalmopathy of Graves disease

Hierarchy of clinical evidence

The anatomical results of patients classified as having a low, intermediate, or high probability of developing three-vessel or left main coronary artery.

[From: Galli : et al: Emergency Orthopedics: The Spine

An algorithm for women who have developed secondary sexual characteristics, have experienced menarche, and are presenting with amenorrhea or oligomenorrhea.

Renin-angiotensin-aldosterone and potassium-aldosterone feedback loops

This diagram illustrates adrenal, ovarian, and testicular steroidogenic pathways. Under the usual circumstances in humans, 17-OHP is a poor substrate for.

Responses of serum insulin to selective intra-arterial calcium stimulation in a patient with biochemical confirmation of inappropriate hyperinsulinism.

(Reproduced, with permission, from Fulop M, et al

Graph of interaction for study of insulin sensitivity

Hypothalamic-pituitary-thyroid axis

Nat. Rev. Endocrinol. doi: /nrendo

Presentation transcript:

Longitudinal effects of aging on date-adjusted testosterone (T) and free testosterone index (free T index). Linear segment plots for total T and free T index versus age are shown for men with T and sex hormone–binding globulin (SHBG) values on at least two visits. Each linear segment has a slope equal to the mean of the individual longitudinal slopes in each decade, and is centered on the median age, for each cohort of men from the second to the ninth decade. Numbers in parentheses represent the number of men in each cohort. With the exception of free T index in the ninth decade, segments show significant downward progression at every age, with no significant change in slopes for T or free T index over the entire age range (T, testosterone; SHBG, sex hormone–binding globulin; T/SHBG, free T index). (Reproduced, with permission, from Harman SM, et al. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. J Clin Endocrinol Metab. 2001;86:724. Copyright 2001 by The Endocrine Society.) Source: Chapter 23. Geriatric Endocrinology, Greenspan’s Basic & Clinical Endocrinology, 9e Citation: Gardner DG, Shoback D. Greenspan’s Basic & Clinical Endocrinology, 9e; 2011 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/gard9/gard9_c023f018.gif&sec=39750906&BookID=380&ChapterSecID=39744063&imagename= Accessed: December 25, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved