Zoledronate Inhibits Intimal Hyperplasia in Balloon-injured Rat Carotid Artery L. Wu, L. Zhu, W.H. Shi, B. Yu, D. Cai European Journal of Vascular and.

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Reviewer Acknowledgment

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Presentation transcript:

Zoledronate Inhibits Intimal Hyperplasia in Balloon-injured Rat Carotid Artery L. Wu, L. Zhu, W.H. Shi, B. Yu, D. Cai European Journal of Vascular and Endovascular Surgery Volume 41, Issue 2, Pages 288-293 (February 2011) DOI: 10.1016/j.ejvs.2010.07.028 Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 1 Haematoxylin and eosin stained photomicrographs of rat right carotid artery sections 21 days after balloon injury at 100× magnification. The scale bar represents 100 μm (a) shows representative artery from group I; (b) shows artery from group II; (c) shows artery from group III; (d) shows artery from group IV. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 2 The medial area of the right carotid artery from all four groups and the left uninjured arteries from group I. The area is calculated as mm2. Data are expressed as mean ± SEM. *P < 0.05 compared with left uninjured arteries from group I. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 3 The intimal area of the right carotid artery of all four groups. The area is calculated as mm2. Data are expressed as mean ± SEM. **P < 0.01 compared with control group. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 4 Intima/Media ratio 21 days after balloon injury of all four groups. **P < 0.01 compared with control group. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 5 PCNA protein expression 21 days after balloon injury at 400× magnification. Positive expression was detected by immunohistochemistry (cells stained in dark brown). The scale bar represents 50 μm (a) shows representative artery from group I; (b) shows artery from group II; (c) shows artery from group III; (d) shows artery from group IV. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions

Figure 6 Effect of systemic and local delivery of zoledronate on the PCNA expression in neo-intima 21 days after balloon injury. **P < 0.01, compared with control group. European Journal of Vascular and Endovascular Surgery 2011 41, 288-293DOI: (10.1016/j.ejvs.2010.07.028) Copyright © 2010 European Society for Vascular Surgery Terms and Conditions