Figure 1. Height distribution for adults with AIS.

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Figure 1. Height distribution for adults with AIS. From: The Contribution of Testosterone to Skeletal Development and Maintenance: Lessons from the Androgen Insensitivity Syndrome J Clin Endocrinol Metab. 2000;85(3):1032-1037. doi:10.1210/jcem.85.3.6428 J Clin Endocrinol Metab | Copyright © 2000 by The Endocrine Society

Figure 2. Box plots of lumbar spine and femoral neck BMD z-scores for 28 adults with AIS. Values were compared to those in the nominal population means by single sample t tests. Clear boxes, Complete AIS (n = 22); hatched boxes, partial AIS (n = 6). These plots illustrate the mean value as a horizontal line. The vertical limits of the box define the 25th and 75th percentiles, and the error bars denote the 10th and 90th percentiles. For complete AIS, spine BMD z-scores were significantly lower than predicted. No BMD deficit at either spine or hip was found for partial AIS. *, P = 0.0003. From: The Contribution of Testosterone to Skeletal Development and Maintenance: Lessons from the Androgen Insensitivity Syndrome J Clin Endocrinol Metab. 2000;85(3):1032-1037. doi:10.1210/jcem.85.3.6428 J Clin Endocrinol Metab | Copyright © 2000 by The Endocrine Society

Figure 3. Box plots of lumbar spine and femoral neck BMD z-scores for 18 women with complete AIS by degree of compliance with estrogen replacement therapy. Teenage subjects, 2 of whom had not yet undergone gonadectomy, were excluded from this analysis. Values were compared to nominal population means by single sample t tests. Clear boxes, Poor and fair compliance; hatched boxes, good and excellent compliance. Interpretation of box plots is described in Fig. 2. *, P = 0.06; **, P = 0.02; ***, P = 0.0001 (compared to normative mean z-score of 0). #, P = 0.005 (good vs. fair compliance). From: The Contribution of Testosterone to Skeletal Development and Maintenance: Lessons from the Androgen Insensitivity Syndrome J Clin Endocrinol Metab. 2000;85(3):1032-1037. doi:10.1210/jcem.85.3.6428 J Clin Endocrinol Metab | Copyright © 2000 by The Endocrine Society

Figure 4. Effect of size adjustment on bone density z-scores for estrogen-compliant women. Box plots on the left show age-specific BMD z-scores. Those on the right show z-scores for BMAD. Interpretation of box plots is described in Fig. 2. *, P < 0.05;** , P < 0.01; #, P = 0.017 (compared to nominal mean population z-scores of 0). From: The Contribution of Testosterone to Skeletal Development and Maintenance: Lessons from the Androgen Insensitivity Syndrome J Clin Endocrinol Metab. 2000;85(3):1032-1037. doi:10.1210/jcem.85.3.6428 J Clin Endocrinol Metab | Copyright © 2000 by The Endocrine Society