No association found between prenatal exposure to PCBs and total serum testosterone in adult male offspring of the Child Health and Development Studies.

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Presentation transcript:

No association found between prenatal exposure to PCBs and total serum testosterone in adult male offspring of the Child Health and Development Studies Linda G. Kahn1, Piera Cirillo2, Barbara Cohn2, June-Soo Park3, Myrto Petreas3, Pam Factor-Litvak1 1 Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 2 Child Health and Development Studies, Berkeley, CA 3 Department of Toxic Substances Control, California Environmental Protection Agency Introduction The coincident rise in widespread use of industrial and agricultural chemicals and reported decline in semen quality and increase in testicular cancer in developed countries has led researchers to hypothesize that persistent organic pollutants such as polychlorinated biphenyls (PCBs) might interfere with the production and/or regulation of male reproductive hormones. In contrast with cross-sectional studies of PCBs and testosterone, which suggest an inverse relationship between the two, investigations into the effect of prenatal PCB exposure on total testosterone have found no association at endpoints ranging from birth through adolescence. In this study, we explore whether this apparent lack of association between prenatal PCB and testosterone persists into adulthood. Results No association found between total prenatal PCBs, individual PCB congeners, and PCB groupings and Total serum testosterone FSH FSH/Testosterone controlling for maternal weight, race, coffee intake and income, and men’s age, smoking status, perceived stress, and total serum lipids. Conclusion Prenatal exposure to PCBs is not associated with total serum testosterone in our data, confirming findings in other birth cohorts that included younger participants. Group 1b PCBs Estrogenic/neurotoxic Mono-ortho PCBs Di-ortho PCBs Tri-ortho PCBs Group 3 PCBs Enzyme-inducing Group 2b PCBs Antiestrogenic (dioxinlike) Group 2a PCBs Antiestrogenic(dioxinlike) Methods Study sample: 196 men who were part of the Child Health and Development Studies birth cohort followed up at mean age 43 Exposures: Prenatal PCBs from stored postpartum maternal blood Total PCBs 15 individual PCB congeners Grouped according to 3 chlorination patterns Grouped according to proposed biological mechanism* Outcomes: Testosterone and follicle stimulating hormone (FSH) in the adult men. PCBs 101, 187 PCBs 66, 74, 105, 118, 156 PCBs 66, 74, 105, 118, 156 PCBs 99, 101, 138, 154, 170, 180, 194 PCBs 138, 170 PCBs 183, 187, 203 PCBs 99, 153, 180, 183, 203 * Wolff MS, Camann D, Gammon M, Stellman SD. Proposed PCB congener groupings for epidemiologic studies. Environ Health Perspect 105(1):13-14 (1995).