From: Two-Year Intraocular Delivery of Ciliary Neurotrophic Factor by Encapsulated Cell Technology Implants in Patients with Chronic Retinal Degenerative Diseases Invest. Ophthalmol. Vis. Sci.. 2012;53(12):7484-7491. doi:10.1167/iovs.12-9970 Figure Legend: Cross-section histology images of CNTF high-dose devices. (A) Prior to implant. (B–E) Following removal at 6, 12, 18, and 24 months, respectively. Viable cells are documented throughout the entire length and width of the internal compartment of all devices. NTC-201 cells are found to attach to the polyethylene terephthalate scaffold (yellow arrows shown for emphasis in image [A] only) while additionally forming cell-to-cell attachments and ultimately populating a majority of the internal space of the device between the scaffolding and the inner wall of the encapsulation membrane (outer bounding structure running parallel on both sides of capsule). All images shown are 4-micron–thick sections, cut approximately at center mass of device, embedded in glycol methacrylate, and stained with hematoxylin and eosin. Images shown are 10× magnification. Date of download: 12/26/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.