Volume 17, Issue 12, Pages (December 2017)

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Volume 17, Issue 12, Pages 1866-1874 (December 2017) Efficacy of Escherichia coli-derived recombinant human bone morphogenetic protein-2 in posterolateral lumbar fusion: an open, active-controlled, randomized, multicenter trial Jae Hwan Cho, MD, Jae Hyup Lee, MD, PhD, Jin Sup Yeom, MD, PhD, Bong-Soon Chang, MD, PhD, Jae Jun Yang, MD, PhD, Ki Hyoung Koo, MD, PhD, Chang Ju Hwang, MD, PhD, Kwang Bok Lee, MD, PhD, Ho-Joong Kim, MD, PhD, Choon-Ki Lee, MD, PhD, Hyoungmin Kim, MD, PhD, Kyung-Soo Suk, MD, PhD, Woo Dong Nam, MD, PhD, Jumi Han, MS The Spine Journal Volume 17, Issue 12, Pages 1866-1874 (December 2017) DOI: 10.1016/j.spinee.2017.06.023 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Flow diagram showing the process of enrollment, allocation, follow-up, and analysis. The Spine Journal 2017 17, 1866-1874DOI: (10.1016/j.spinee.2017.06.023) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Characteristics of fusion mass taken in postoperative 12 weeks. (A) Fusion mass in a radiograph in the E.BMP-2 group (arrows). (B) Remaining HA carrier without resorption in the E.BMP-2 group. (C) Fusion mass in a radiograph in the AIBG group (arrows) (D) Continuously fused mass in the AIBG group. AIBG, autogenous iliac bone graft; E.BMP-2, Escherichia coli-derived recombinant human bone morphogenetic protein-2; HA, hydroxyapatite. The Spine Journal 2017 17, 1866-1874DOI: (10.1016/j.spinee.2017.06.023) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Comparison of clinical parameters between the groups. (A) Oswestry Disability Index (ODI), (B) Short Form-36 (SF-36), (C) Visual analogue scale (VAS) (lumbar), (D) VAS (left leg), (E) VAS (right leg). AIBG, autogenous iliac bone graft; E.BMP-2, Escherichia coli-derived recombinant human bone morphogenetic protein-2. The Spine Journal 2017 17, 1866-1874DOI: (10.1016/j.spinee.2017.06.023) Copyright © 2017 The Authors Terms and Conditions