W. H. A. M. MULDERS* AND D. ROBERTSON

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Presentation transcript:

W. H. A. M. MULDERS* AND D. ROBERTSON PROGRESSIVE CENTRALIZATION OF MIDBRAIN HYPERACTIVITY AFTER ACOUSTIC TRAUMA W. H. A. M. MULDERS* AND D. ROBERTSON Presenter: Danyi LU Neuroscience 192 (2011) 753–760

spontaneous firing rates (SFRs) what's new spontaneous firing rates (SFRs) Acoustic trauma Central hyperactivity Early stage: continued peripheral afferent input Later stage: intrinsically generated within the central nervous system Abbreviation: spontaneous firing rates -SFRs inferior colliculus -IC central nucleus of the inferior colliculus -CNIC compound action potential-CAP

EXPERIMENTAL PROCEDURES overall experimental design

EXPERIMENTAL PROCEDURES 1.animals 2.anesthesia and surgery 3.inferior colliculus recording* 4.cochlear ablation 5.data analysisi

RESULTS-Cochlear thresholds

RESULTS-Cochlear thresholds

RESULTS-Summary of all data

RESULTS-Hyperactivity in CNIC

RESULTS-Effects of cochlear ablation on hyperactivity

RESULTS-Comparison with shorter recovery data

RESULTS-elevated SFRs in CNIC neurons after acoustic trauma were more commonly observed in CF regions of the CNIC that correlate with the frequencies in the cochlea

Discussion-differential effect of cochlear ablation at the two stages

Recent-onset Tinnitus Long-standing Tinnitus Significance Important consequences for possible mechanisms and treatment of tinnitus Recent-onset Tinnitus Long-standing Tinnitus