Down-regulated genes in evolved normomutable variants Down-regulated genes in evolved mutator variants (186 genes) Siderophores and secundary metabolites biosynthesis Tricarboxylic acid cycle Fatty acid metabolism Pyruvate biosynthesis and metabolism Aminoacid biosynthesis and metabolism Sugars biosynthesis and metabolism Nitrogen metabolism Permeases Membrane transport Translation ribosomal Transcription Transcriptional regulators Signal transduction Oxidative phosphorilation Cell motility Fimbriae Others Unknown and hypothetical protein 5 10 15 20 25 30 35 Siderophores and secundary metabolites biosynthesis Tricarboxylic acid cycle Fatty acid metabolism Pyruvate biosynthesis and metabolism Aminoacid biosynthesis and metabolism Sugars biosynthesis and metabolism Nitrogen metabolism Permeases Membrane transport Translation ribosomal Transcription Transcriptional regulators Signal transduction Oxidative phosphorilation Cell motility Fimbriae Others Unknown and hypothetical protein