Suppl 4A Large black circles: query genes

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Suppl 4A Large black circles: query genes Grey circles: interacting or related proteins Purple: Co expression Light blue: Colocalization Light green: genetic interactions Functions 1. Negative regulation of motility 2. Androgen metabolism 3. Hydrolase activity

Suppl 4B Functions 1. Small molecule biosynthesis 2. Steroid metabolism 3. Alcohol metabolism 4. Cholesterol metabolism 5. Sterol metabolism 6. Organic hydroxy compounds, carboxylic acid, organic acid and fatty acid metabolism (including fatty acid beta oxidation)

Suppl 4C Light grey: consolidated pathways Red: Physical interactions Blue: Pathway Functions 1. GPI anchor bioassembly in ER membrane 2. C-terminal amino acid modification 3. Protein lipidation 4. Glycolipid, lipoprotein, phosphatidylinositol biosynthesis 5. Glycerophospholipid metabolism 6. Fibroblast growth factor and insulin receptor receptor signaling pathway 7. Transferase, mannosyltransferase, phosphotransferase activity 8. Positive regulator of ERK1/ERK2 cascade

Suppl 4D Purple: Co-expression Functions 1. SRP dependent cotranslational protein targeting to membrane 2. Cytosolic ribosome 3. Translation elongation and termination 4. Protein localization to ER 5. Nonsense mediated decay of mRNA 6. Viral genome expression, reproduction

Suppl 4E Light blue: Pathways Yellow: Predicted interaction Light grey: consolidated pathways Functions 1. Cellular response to metal ions (zinc, cadmium, inorganic metals, transition metals) 2. Negative regulation of growth 3. Primary alcohol metabolic process 4. Oxidoreductase activity

Suppl 4F Light grey: transcription factor targets