Mechanisms of action of established and experimental drugs used for the chemotherapy of mycobacterial infections. Approved drugs for the chemotherapy of.

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Mechanisms of action of established and experimental drugs used for the chemotherapy of mycobacterial infections. Approved drugs for the chemotherapy of mycobacterial diseases may be grouped according to the sites of action indicated by the pictures above that expand regions of the mycobacterium: inhibitors of nucleic acid and protein synthesis; disruptors of cell wall and cell membrane synthesis; inhibitors of membrane transport. Specific antimycobacterial agents and their mechanisms of action are also listed. Rifamycin is used as a generic term for several drugs, of which rifampin is used most frequently. Clofazimine, whose mode of action is not understood, is omitted. Source: Chemotherapy of Tuberculosis, Mycobacterium avium Complex Disease, and Leprosy, Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e Citation: Brunton LL, Hilal-Dandan R, Knollmann BC. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e; 2017 Available at: https://accesspharmacy.mhmedical.com/DownloadImage.aspx?image=/data/books/2189/goodman13_ch60_f001_u.png&sec=172485539&BookID=2189&ChapterSecID=172485532&imagename= Accessed: December 26, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved