Volume 100, Issue 10, Pages (October 2006)

Slides:

Advertisements

Similar presentations

COPD case finding by spirometry in high-risk customers of urban community pharmacies: A pilot study D. Castillo, R. Guayta, J. Giner, F. Burgos, C. Capdevila,

Advertisements

Association of heart diseases with COPD and restrictive lung function – Results from a population survey Berne Eriksson, Anne Lindberg, Hana Müllerova,

Obstructive lung disease in children with mild to severe BPD Eva Berggren Broström, Per Thunqvist, Gunilla Adenfelt, Elisabeth Borling, Miriam Katz-Salamon.

Lactate dehydrogenase as prognostic factor in limited and extensive disease stage small cell lung cancer – A retrospective single institution analysis.

Adherence to pulmonary rehabilitation: A qualitative study

Volume 104, Issue 12, Pages (December 2010)

Volume 101, Issue 12, Pages (December 2007)

Volume 102, Issue 1, Pages (January 2008)

Volume 100, Issue 2, Pages (February 2006)

Volume 109, Issue 8, Pages (August 2015)

Volume 100, Issue 10, Pages (October 2006)

Pedro Chorão, Ana M. Pereira, João A. Fonseca Respiratory Medicine

Erik Ames, Salif Harouna, Colin Meyer, Lisbeth A. Welniak, William J

Ted Klok, Adrian A. Kaptein, Eric J. Duiverman, Paul L. Brand

Volume 108, Issue 2, Pages (February 2014)

Volume 101, Issue 6, Pages (June 2007)

Volume 103, Issue 4, Pages (April 2009)

Volume 107, Issue 10, Pages (October 2013)

Identifying poor compliance with CPAP in obstructive sleep apnoea: A simple prediction equation using data after a two week trial Dipansu Ghosh, Victoria.

A double-blind randomized study of aminoglycoside infusion with combined therapy for pulmonary Mycobacterium avium complex disease Yoshihiro Kobashi,

Volume 100, Issue 1, Pages (January 2006)

A pilot study of an Internet walking program and pedometer in COPD

Volume 100, Issue 6, Pages (June 2006)

Tracheobronchial haemorrhage in patients with neuromuscular disorders

Volume 100, Issue 5, Pages (May 2006)

Volume 99, Issue 12, Pages (December 2005)

Edward G. Seferian, Nancy K. Henry, Mark E. Wylam Respiratory Medicine

Céline Pynnaert, Michel Lamotte, Robert Naeije Respiratory Medicine

Noninvasive ventilation in pulmonary rehabilitation of COPD patients

Volume 39, Issue 5, Pages (November 2013)

Simple versus complex COPD: implications for health-care management

Reduced Frequency of Regulatory T Cells in Peripheral Blood Stem Cell Compared to Bone Marrow Transplantations Céline Blache, Joe-Marc Chauvin, Aude.

Rabbit Anti T-Lymphocyte Globulin Induces Apoptosis in Peripheral Blood Mononuclear Cell Compartments and Leukemia Cells, While Hematopoetic Stem Cells.

COPD and asthma: the emergency is clear, now is the time for action

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease Alison.

Pathways Responsible for Human Autoantibody and Therapeutic Intravenous IgG Activity in Humanized Mice Inessa Schwab, Anja Lux, Falk Nimmerjahn Cell.

COPD and asthma: the emergency is clear, now is the time for action

Volume 16, Issue 1, Pages (July 2014)

Blood eosinophils as a marker of eosinophilic exacerbations in COPD

A novel neutrophil derived inflammatory biomarker of pulmonary exacerbation in cystic fibrosis Emer P. Reeves, David A. Bergin, Sean Fitzgerald, Elaine.

Volume 39, Issue 2, Pages (August 2013)

PreImplantation Factor Reduces Graft-versus-Host Disease by Regulating Immune Response and Lowering Oxidative Stress (Murine Model) Yehudith Azar, Reut.

Morphogens: Precise Outputs from a Variable Gradient

SDC 2 - Figure S1.

Mass cytometry profiling the response of basophils and the complete peripheral blood compartment to peanut Leticia Tordesillas, PhD, Adeeb H. Rahman,

A Reducing Microenvironment Leads to the Generation of FcεRIhigh Inflammatory Dendritic Epidermal Cells (IDEC) Natalija Novak, MD, Stefan Kraft, Jörg.

Increased Lipocalin-2 Contributes to the Pathogenesis of Psoriasis by Modulating Neutrophil Chemotaxis and Cytokine Secretion Shuai Shao, Tianyu Cao,

Volume 39, Issue 5, Pages (November 2013)

Katherine N. Cahill, MD, Jillian C. Bensko, Joshua A

Thymic stromal lymphopoietin activation of basophils in patients with allergic asthma is IL-3 dependent Brittany M. Salter, BSc, John Paul Oliveria,

Increased serum concentration of G-CSF in cystic fibrosis patients with chronic Pseudomonas aeruginosa pneumonia P.Ø. Jensen, C. Moser, A. Kharazmi,

TSLP Directly Interacts with Skin-Homing Th2 Cells Highly Expressing its Receptor to Enhance IL-4 Production in Atopic Dermatitis Kazuki Tatsuno, Toshiharu.

Expression of activated FcγRII discriminates between multiple granulocyte-priming phenotypes in peripheral blood of allergic asthmatic subjects Deon.

Volume 42, Issue 6, Pages (June 2015)

Michael J. Mitchell, Michael R. King Biophysical Journal

Volume 59, Issue 3, Pages (March 2001)

Shilpi Saha, Subhra K. Biswas Cancer Cell

Increased, but Functionally Impaired, CD14+ HLA-DR–/low Myeloid-Derived Suppressor Cells in Psoriasis: A Mechanism of Dysregulated T Cells David C. Soler,

Volume 22, Issue 3, Pages (March 2005)

Volume 77, Issue 2, Pages (January 2010)

Mammalian target of rapamycin inhibition counterbalances the inflammatory status of immune cells in patients with chronic granulomatous disease Aurélie.

Persistence of host dendritic cells after transplantation is associated with graft-versus- host disease Geoffrey W. Chan, Gullu Gorgun, Kenneth B. Miller,

Volume 38, Issue 3, Pages (March 2013)

Volume 41, Issue 1, Pages (July 2014)

Eosinophilia and gastrointestinal symptoms after ingestion of shiitake mushrooms Aaron M. Levy, MDa, Hirohito Kita, MDb, Sidney F. Phillips, MDa, Paul.

Interleukin-17A Promotes IgE Production in Human B Cells

Mechanism of topical glucocorticoid treatment of hay fever: IL-5 and eosinophil activation during natural allergen exposure are suppressed, but IL-4,

Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients Y.John Gu, MD, PhD, Pieter Schoen,

Volume 55, Issue 5, Pages (May 1999)

Endogenous Control of Immunity against Infection: Tenascin-C Regulates TLR4- Mediated Inflammation via MicroRNA-155 Anna M. Piccinini, Kim S. Midwood

Presentation transcript:

Volume 100, Issue 10, Pages 1791-1799 (October 2006) Expression of priming-associated cellular markers on neutrophils during an exacerbation of COPD Erik-Jan D. Oudijk, Wim B.M. Gerritsen, Evert H.J. Nijhuis, Deon Kanters, Boudewijn L.P. Maesen, Jan-Willem J. Lammers, Leo Koenderman Respiratory Medicine Volume 100, Issue 10, Pages 1791-1799 (October 2006) DOI: 10.1016/j.rmed.2006.01.022 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 GM-CSF (1–0.001nM)-induced expression of priming epitopes on neutrophils of normal donors recognized by FITC-labeled MoPhaps A17 and A27 is shown in panel (A) and (B), respectively. In panel (C), a comparative analysis of expression of activation epitopes recognized CD11b, CD18, CD 62L and CD 63 antibodies on neutrophils stimulated with 1nM GM-CSF are shown. The antibodies were directly labeled with FITC or PE. The expression of priming markers is shown as the mean-fold increase of the GM-CSF stimulated sample compared to the unstimulated sample (error bars±sem, n=7, *P<0.05). Respiratory Medicine 2006 100, 1791-1799DOI: (10.1016/j.rmed.2006.01.022) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 2 The effect of 1-week treatment of patients with an exacerbation of COPD on expression of priming epitopes on neutrophils. (A) MoPhab A17 expression on circulating neutrophils, (B), MoPhab A27 expression on circulating neutrophils. Data are presented as individual values (median fluorescence intensity, n=10) and as means of the 10 individual experiments. The expressions of MoPhab A17 and A27 were significantly increased ad admission compared to the follow-up days. Respiratory Medicine 2006 100, 1791-1799DOI: (10.1016/j.rmed.2006.01.022) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 3 The effect of 1-week treatment of patients with an exacerbation of COPD on (A) exhaled H2O2, (B) lung function (FEV1) and (C) (Borg) dyspnea score. Data are shown as individual values (n=10) and as means. Respiratory Medicine 2006 100, 1791-1799DOI: (10.1016/j.rmed.2006.01.022) Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 4 Correlations between markers of systemic inflammation and local inflammatory markers. H2O2 concentration in exhaled air, a marker for local inflammation correlates with moPhab A27 expression on peripheral blood neutrophils (A) and not with moPhab A17 (B). In addition, the Borg score correlated with H2O2 concentration in exhaled air (C) and with moPhab A27 expression on peripheral blood neutrophils (D). Every point represents the values corresponding to an individual subject during the study period and fluorescence is expressed as median fluorescent intensity. Correlation coefficients (Pearson) and P values are shown in each figure. Respiratory Medicine 2006 100, 1791-1799DOI: (10.1016/j.rmed.2006.01.022) Copyright © 2006 Elsevier Ltd Terms and Conditions