Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic.

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Type 2 deiodinase Thr92Ala polymorphism is associated with disrupted placental activity but not with dysglycemia or adverse gestational outcomes: a genetic association study José Miguel Dora, M.D., Ph.D., Simone M. Wajner, M.D., Ph.D., Juliano Dalla Costa, Rafaela Vanin Pinto Ribeiro, Leonardo Barbosa Leiria, Ph.D., Mariah G. Lopes, M.D., Aline Vitali da Silva, M.D., Daisy Crispim, Ph.D., Ana Luiza Maia, M.D., Ph.D. Fertility and Sterility Volume 101, Issue 3, Pages 833-839.e1 (March 2014) DOI: 10.1016/j.fertnstert.2013.11.018 Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Fasting glucose during pregnancy and 2-hour glucose in the oral glucose tolerance test with 75 g of glucose (2-hour OGTT 75 g) in the third trimester of pregnancy, according to D2 Thr/92Ala genotypes, assuming a recessive model of inheritance. Comparisons of fasting glucose in the first (P=.65), second (P=.79), and third (P=.20) trimesters, and 2-hour OGTT 75 g (P=.50) in the third trimester of pregnancy were not different across Ala/Ala and Thr/Ala-Thr/Thr genotypes. Values are expressed as mean ± standard error. Fertility and Sterility 2014 101, 833-839.e1DOI: (10.1016/j.fertnstert.2013.11.018) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Placental type 2 deiodinase (D2) mRNA expression (A) and activity (B) according to D2 Thr92Ala genotypes. There were no differences across genotypes regarding D2 mRNA expression (P=.91), but D2 activity was reduced in the Ala/Ala group (P<.001). Values are expressed as mean ± standard error. AU = arbitrary units. Fertility and Sterility 2014 101, 833-839.e1DOI: (10.1016/j.fertnstert.2013.11.018) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Placental type 3 deiodinase (D3) mRNA expression (A) and activity (B), according to D2 Thr92Ala genotypes. There were no differences in D3 mRNA expression (P=.15) or activity (P=.35) across groups. Values are expressed as mean ± standard error. AU = arbitrary units. Fertility and Sterility 2014 101, 833-839.e1DOI: (10.1016/j.fertnstert.2013.11.018) Copyright © 2014 American Society for Reproductive Medicine Terms and Conditions