Volume 19, Issue 11, Pages (November 2017)

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Volume 19, Issue 11, Pages 928-931 (November 2017) Endothelial Cells as Precursors for Osteoblasts in the Metastatic Prostate Cancer Bone Ana E. Paiva, Luiza Lousado, Viviani M. Almeida, Julia P. Andreotti, Gabryella S.P. Santos, Patrick O. Azevedo, Isadora F.G. Sena, Pedro H.D.M. Prazeres, Isabella T. Borges, Vasco Azevedo, Akiva Mintz, Alexander Birbrair Neoplasia Volume 19, Issue 11, Pages 928-931 (November 2017) DOI: 10.1016/j.neo.2017.08.007 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Endothelial cells form osteoblasts in the metastatic prostate cancer bone. Prostate cancer metastases induce ectopic bone formation, which cooperates with prostate cancer progression. Understanding the cellular mechanisms involved in this process is a central question in prostate tumor biology. Lin and colleagues recently showed that endothelial cells, stimulated by malignant cells via BMP4, generate osteoblasts [14]. Future studies may reveal the complexity of the bone microenvironment invaded by prostate tumor cells in much greater detail. Neoplasia 2017 19, 928-931DOI: (10.1016/j.neo.2017.08.007) Copyright © 2017 The Authors Terms and Conditions