Copyright © 2009 American Medical Association. All rights reserved. From: Progression of Age-Related Macular Degeneration After Cataract Surgery Arch Ophthalmol. 2009;127(11):1412-1419. doi:10.1001/archophthalmol.2009.152 Figure Legend: Example of a case enrolled in which the enrolling ophthalmologist did not identify any choroidal neovascularization (CNV), but the reading center graders identified CNV at baseline. The top row of images shows a hazy color fundus photograph (A), hazy bright fluorescence judged by reading center graders to be caused by CNV (B), and hazy bright fluorescence judged by reading center graders to be leakage from CNV (C). D, One week after cataract surgery, obvious CNV recurring at the edge of a prior area of laser treatment is identified. E, Bright fluorescence from CNV adjacent to hypofluorescence of a prior area of laser treatment is seen. F, Staining of laser treatment shows additional leakage from recurrent CNV along the foveal side of the laser-treated area. Date of download: 12/26/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Progression of Age-Related Macular Degeneration After Cataract Surgery Arch Ophthalmol. 2009;127(11):1412-1419. doi:10.1001/archophthalmol.2009.152 Figure Legend: Example of no choroidal neovascularization (CNV) identified at baseline by either the enrolling ophthalmologist or the reading center graders, with CNV identified by the reading center graders at week 1, and then noted more obviously at month 12. The top row shows a hazy color fundus photograph (A) with early-phase fluorescein angiogram (B) and late-phase fluorescein angiogram (C) identified as showing no definitive CNV, with abnormalities judged to be from drusen and retinal pigment epithelial abnormalities caused by age-related macular degeneration. The middle row shows no obvious CNV on color fundus photographs 1 week after cataract surgery (D), but the late-phase fluorescein angiogram frame (E) was interpreted as having fluorescein leakage from CNV along the inferior portion of the macula, with additional speckled fluorescence temporal and inferior to this leakage interpreted as late leakage of an undetermined source not noted on the earlier-phase fluorescein angiogram frame (F), a pattern of occult CNV. The month 12 fundus photograph (G) shows no obvious CNV, but midphase (H) and late-phase (I) fluorescein angiograms show more definitive leakage from occult CNV. Date of download: 12/26/2017 Copyright © 2009 American Medical Association. All rights reserved.

Copyright © 2009 American Medical Association. All rights reserved. From: Progression of Age-Related Macular Degeneration After Cataract Surgery Arch Ophthalmol. 2009;127(11):1412-1419. doi:10.1001/archophthalmol.2009.152 Figure Legend: Example of no choroidal neovascularization (CNV), noted by ophthalmologist or reading center graders at baseline or at week 1, with CNV identified by reading center graders at month 12. The top row shows a color fundus photograph (A) that is hazy from cataract but shows no CNV, as documented on fluorescein angiography in the early and late phase (B and C). One week after cataract surgery, fundus photograph (D) and early- and late-phase fluorescein angiogram frames (E and F, respectively) show staining of drusen and retinal pigment epithelium abnormalities, but no leakage. One year after cataract surgery, a color fundus photograph shows no obvious CNV (G), but fluorescein angiography in the early and late phases (H and I, respectively) shows a small area of leakage caused by CNV just inferotemporal to the foveal center. Date of download: 12/26/2017 Copyright © 2009 American Medical Association. All rights reserved.