Formative Test

(A) A decrease in preload (B) A decrease in afterload Q1- A woman is prescribed a combination of drugs consisting of a nitroglycerin patch and propranolol, to treat her attacks of secondary angina. Which effect of propranolol would counteract an adverse effect of nitroglycerin? (A) A decrease in preload (B) A decrease in afterload (C) A increase in heart rate (D) An decrease in myocardial contractile force (E) A reduction in coronary vasospasm

(A) Block of exercise-induced tachycardia Q2- The antianginal effect of propranolol may be attributed to which one of the following? (A) Block of exercise-induced tachycardia (B) Decreased end-diastolic ventricular volume (C) Dilation of constricted coronary vessels (D) Increased cardiac force (E) Increased resting heart rate

Q3- A 69-year-old male with angina develops severe constipation following treatment with:- Propranolol Nitroglycerine Verapamil Nicorandil Ranolazine

Q4- Beneficial effects of calcium channel blockers in managing angina include all of the following except:- a- decreased arterial and intraventricular pressure b- reduced afterload c- decreased myocardial wall tension d- decreased myocardial contractile force e- decreased preload

Q5- The management of unstable angina usually includes:- (A) aspirin (B) nitroglycerine (C) β-blockers (D) low molecular weight heparin (E) all of the above

Q6- Select the drug which is a potassium channel opener as well as nitric oxide donor:- (A) Amlodepine (B) Ranolazine (C) Isradepine (D) Minoxidil (E) Nicorandil

Q7- Ranolazine produces all of the following effects except:- (A) inhibits a late sodium current that facilitates calcium entry (B) is a partial fatty acid oxidation inhibitor (C) shifts myocardial metabolism toward greater use of glucose (D) causes hypotension (E) reduces the oxygen demand

Q8- An active metabolite of another drug and an active antianginal drug for oral administration in its own right. (A) Isosorbide dinitrate (B) Amylnitrite (C) Isosorbide mononitrate (D) Nitroglycerin (E) Pentaerythritol tetranitrate

Q9- Nitroglycerin produces all the following effects except:- (A) relaxes vascular smooth muscles (B) is associated with tolerance more commonly with transdermal patches than sublingual tablets (C) causes reflex tachycardia (D) is relatively more selective for arteriolar than for venous smooth muscles (E) may relieve biliary colic

Q10- A side effect least likely to be seen with nitroglycerin: A-  headache B- dizziness C-  palpitations   D- cancer of oesophagus E- flushing