Mohammad H. Eslami, MDa, Sidhu P

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Presentation transcript:

Monocyte adhesion to human vein grafts: A marker for occult intraoperative injury? Mohammad H. Eslami, MDa, Sidhu P. Gangadharan, MDb, Michael Belkin, MDb, Magruder C. Donaldson, MDb, Anthony D. Whittemore, MDb, Michael S. Conte, MDb Journal of Vascular Surgery Volume 34, Issue 5, Pages 923-929 (November 2001) DOI: 10.1067/mva.2001.118590 Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 THP-1 adhesion to vein segments from lower-extremity bypass procedures. There is a significant increase in monocyte adhesion to the V2 segments that were subjected to surgical manipulation and brief arterialization. SVG , Saphenous vein graft. Journal of Vascular Surgery 2001 34, 923-929DOI: (10.1067/mva.2001.118590) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Immunohistochemical staining for Fg on vein segments from lower-extremity grafting procedures. No staining was noted in unmanipulated V1 segments (right ). V2 segments demonstrated diffuse areas of luminal staining (left ). Journal of Vascular Surgery 2001 34, 923-929DOI: (10.1067/mva.2001.118590) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Graft occlusions at 1 year versus monocyte adhesion; the median value of monocyte adhesion (V2 values) for the grafts that remained patent at 1 year was 3892 cell/cm2 versus 6234 cell/cm2 for the occluded grafts (P =.07). Journal of Vascular Surgery 2001 34, 923-929DOI: (10.1067/mva.2001.118590) Copyright © 2001 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions