HEIGHT-AGE-SEX SPECIFIC BODY MASS INDEX IN CHILDREN WITH END STAGE RENAL DISEASE - SINGLE CENTER EXPERIENCE 1 Fundeni Clinical Institute, Bucharest, Romania.

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HEIGHT-AGE-SEX SPECIFIC BODY MASS INDEX IN CHILDREN WITH END STAGE RENAL DISEASE - SINGLE CENTER EXPERIENCE 1 Fundeni Clinical Institute, Bucharest, Romania – Pediatric Dialysis and Nephrology Department AUTHORS Adrian Catalin Lungu1 Oana Piscoran2 2 Sf. Ioan Clinical Hospital, Nephrology Ana-Maria Pop1 Cristina Stoica1 INTRODUCTION AND AIMS: Growth failure is a common complication in children with End Stage Renal Disease (ESRD) either on Hemodialysis (HD) or Peritoneal Dialysis (PD). The aim was to observe the correlation between Body Mass Index (BMI) and Dialysis Vintage in children on Renal Replacement Therapy (RRT). Correlations DiaModality BMIzScore DiaVintage HD Pearson 1 -.220 .a Sig. (2-tailed) .234 . N 31 Pearson Correlation DP -.549** .007 23 METHODSs: Single center, retrospective study on 54 pediatric ESRD patients, age 5-19 years, median age 15.66 ± 3.2 years, 35 boys, 19 girls, 30 on HD, 24 on PD. Growth was quantified as specific BMI standard deviation scores (z). None of the patients received Growth Hormone Therapy. Median Dialysis Vintage was 40.77 ± 32.4 months. To realize the correlations we used the Bivariate Pearson Coefficient. RESULTS: BMI z Score median value: -1.99 ± 1.61, correlates with Dialysis Vintage (R2 = 0.118, p<0.05). We compared the correlations by splitting the cohort in groups by Sex, Dialysis Vintage and Chronic Kidney Disease (CKD) cause. In our study group, between BMI z Score and Dialysis Vintage, there was a stronger negative correlation for girls (R2 = 0.180, p=0.07) than for boys (R2 = 0.6, p=0.65), a very strong negative correlation for the kids on PD (R2 = 0.301, p=0.007) and a week negative one for the kids on HD (not statistically significant) (R2 = 0.049, p=0.234). Regarding the CKD cause, we found strong negative correlations for the Malformation group (R2 = 0.228, p=0.006), but no correlation for the Glomerular Disease group (R2 Linear = 0.003, p=0.84). Correlations Sex BMIzScore DiaVintage Boys Pearson Correlation 1 -.315 .a Sig. (2-tailed) .065 . N 35 Girls -.424 .070 19 CONCLUSIONS: Our results suggest that even if there is a negative correlation between BMI z Score and Dialysis Vintage, this correlation is stronger in girls than in boys. An important factor that influenced the results was the CKD cause. The children with Urinary Tract Malformations presented longer Dialysis Vintage (mean = 45.3 ± 36.7 months) than the children with Glomerular Disease (mean 34.8 ± 24.9) and with lower BMI z Score median values (-1.92 ± 1.61 than -1.77 ± 1.66). We can conclude that the duration of CKD before the start of RRT is an important factor that conducts to stronger negative correlations between BMI z Score and Dialysis Vintage. Correlations CKDcause BMIzScore DiaVintage Glomerulonephritis Pearson Correlation 1 .057 Sig. (2-tailed) .841 N 15 Malformation -.477** .006 32 Genetic -.533 .355 5 Other -1.000** . 2 AKNOWLEDGEMENT: This paper is supported by the Sectorial Operational Programme in Human Resources Development (SOP HRD), financed from the European Social Fund and by the Romanian Government under the contract number POSDRU/159/1.5/s/137390/ Contact: Dr. Adrian Lungu +40722131950, adilungu@mediakompass.ro 916-SP