Volume 118, Issue 6, Pages 1025-1030 (June 2000) Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy  Jean–frédéric Colombel, Nicolas Ferrari, Hervé Debuysere, Philippe Marteau, Jean–pierre Gendre, Bruno Bonaz, Jean-claude Soulé, Robert Modigliani, Yvan Touze, Pascale Catala, Christian Libersa, Franck Broly  Gastroenterology  Volume 118, Issue 6, Pages 1025-1030 (June 2000) DOI: 10.1016/S0016-5085(00)70354-4 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Delay (months) between the first administration of AZA/6-MP and the occurrence of bone marrow toxicity. Patients classified as low methylators (LM; n = 4) were homozygous for 1 nonfunctional mutation or heterozygous for 2 nonfunctional mutations; patients classified as intermediate methylators (IM; n = 7) were heterozygous for 1 nonfunctional mutation; and patients classified as high methylators (HM; n = 29) were homozygous for the wild-type or heterozygous for 2 functional alleles. One patient was heterozygous for a previously unknown mutation. Gastroenterology 2000 118, 1025-1030DOI: (10.1016/S0016-5085(00)70354-4) Copyright © 2000 American Gastroenterological Association Terms and Conditions