Model Building of DNA

Early efforts to make a DNA model

Watson’s Early attempt To create Double Helix

Jerry Donohue: Worked on dNTPs Told Watson that It was the Keto form Found under physiological conditions

B-DNA

B-DNA

http://www.pbs.org/wgbh/nova/tech/DNA-photograph.html

STACKING OF BASES

A-DNA, B-DNA and Z-DNA The Z-DNA helix is left-handed and has a structure that repeats every 2 base pairs. The major and minor grooves, unlike A- and B-DNA, show little difference in width

B-DNA and Z-DNA

A-DNA, B-DNA and Z-DNA

Lambda repressor

EcoRV