Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis An Tran-Duy, Bart Spaetgens, Arno.

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Presentation transcript:

Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis An Tran-Duy, Bart Spaetgens, Arno W. Hoes, Niek J. de Wit, Coen D.A. Stehouwer Clinical Gastroenterology and Hepatology Volume 14, Issue 12, Pages 1706-1719.e5 (December 2016) DOI: 10.1016/j.cgh.2016.05.018 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Flow chart of study selection. Clinical Gastroenterology and Hepatology 2016 14, 1706-1719.e5DOI: (10.1016/j.cgh.2016.05.018) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Forest plots of (A) odds ratios for gastric polyps and (B) risk ratios of gastric cancer in patients receiving proton pump inhibitors compared with subjects not receiving proton pump inhibitors. CC, case-control study; CH, cohort study; GC, gastric cancer; GCA, gastric cardia adenocarcinoma; GNCA, gastric noncardia adenocarcinoma; GPs, gastric polyps. Clinical Gastroenterology and Hepatology 2016 14, 1706-1719.e5DOI: (10.1016/j.cgh.2016.05.018) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 Forest plots of (A) odds ratios for fundic gland polyps and (B) risk ratios of gastric cancer in subgroups of patients receiving proton pump inhibitors for different durations compared with subjects not receiving proton pump inhibitors. GC, gastric cancer; GCA, gastric cardia adenocarcinoma; GNCA, gastric noncardia adenocarcinoma. Clinical Gastroenterology and Hepatology 2016 14, 1706-1719.e5DOI: (10.1016/j.cgh.2016.05.018) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Funnel plot for detection of possible bias of publication on the effect of proton pump inhibitor use on gastric polyps. Clinical Gastroenterology and Hepatology 2016 14, 1706-1719.e5DOI: (10.1016/j.cgh.2016.05.018) Copyright © 2016 AGA Institute Terms and Conditions