Eye Movements: Good Marker of Methylphenidate efficiency in ADHD M. Seassau (1), T. Weiss (2), R. Carcangiu (2), F. Duval (2) World Congress ADHD, Glasgow 2015 1 e(ye)BRAIN, France 2 Centre Hospitalier Rouffach, Pôle 8/9, France Contact : magali@eye-brain.com 1 Introduction Attention-Deficit/hyperactivity disorder (ADHD) is characterized by behavioral symptoms of inattention and may include hyperactivity and impulsivity. The impulsivity and inattention suggest deficits in the voluntary control of behavior. Eye movements depend on structures implicated in attention and in motor control, both criteria areas of dysfunction in ADHD. In the present study, objective was to evaluate the effect of methylphenidate (MPH) using eye movements in ADHD patients, naïve to treatment. 2 APPARATUS Eye movements were recorded by video-oclography with the Mobile EBT (Medical Device CE-marqued, EyeBrain). Frequency of acquisition is 300 Hz for both eyes. MobileEBT EyeBrain; CE Gap 3 METHODS Fifty nine ADHD patients (44 adults and 15 children) participated to this study. Saccade and antisaccade tasks were proposed to drug naïve patients during a first examination (V1) early in the morning (T1) and at midday (T2). Same tasks were then proposed during a second examination (V2), just after the first dose of MPH (10 mg per os). Step (Horizontal) Step (Vertical) Overlap MPH efficiency was measured by the comparison of V1 and V2. Test-retest effect was measured between T1 and T2. Latencies, mean velocities, precision (gain), accuracy and percentage of anticipatory errors were analyzed. V1 First Exam Off-MPH V2 Second Exam On-MPH T1 (8:00 am) . Eye Movements tests . Cognitive Tests . Neuropsychological Evaluation . Eye Movements Tests T2 (12:00 am) . Eye Movements retests Antisaccades 4 RESULTATS We found a positive effect of MPH on percentage of anticipatory (p<0.009); on accuracy (p<0.0002); on latencies (p<0.0008); and on gain (p<0.01). Performances were significantly better On-MPH than Off-MPH, particularly on antisaccades tasks. Standard deviations were also shorter On-MPH compared to Off-MPH (p<0.0001). Same pattern of performances was observed on adults and on children. Importantly, no test-retest effect was observed between T1 and T2. Adults Children Off-MPH Off-MPH * On-MPH On-MPH * * * * * * * * * * * * * * * * * * * * 5 CONCLUSIONS MPH modified motor planning and response inhibition in ADHD patients. Benefits could be observed using reflexive saccades and antisaccades just after the first dose of MPH. These results suggest that eye movements could be a good marker of MPH efficiency in ADHD. Test-Restest Effect