Copyright © 2013 American Physiological Society

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1 Chapter 24 - Renal Cortical and Medullary Microcirculations: Structure and Function Copyright © 2013 Elsevier Inc. All rights reserved.

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Copyright © 2013 American Physiological Society Fig. 1. Intrarenal oxygenation and medullary tubular function in stenotic (STK) and sham kidneys with or without obesity-metabolic derangement (ObM; n = 7 each). A: representative kidney blood oxygen level-dependent (BOLD)-MRI images obtained at baseline and after furosemide. Dashed lines (white) demarcate the zone encompassing the medullary regions. Cross-lines (black) differentiate vessels from hypoxic regions. B: oxygenation level (R2*) in the cortex. Renal artery stenosis (RAS) decreased cortical oxygenation level (increased R2*) in both Lean-STK and ObM-STK groups. C and D: oxygenation level in the medulla and its response to furosemide. Impaired tubular transport function was indicated in ObM-STK. ♠RAS: significant effect of RAS (2-way ANOVA). *P < 0.05 vs. Lean-sham; #P < 0.05 vs. pre-furosemide (paired t-test). Published in: Xin Zhang; Zi-Lun Li; John R. Woollard; Alfonso Eirin; Behzad Ebrahimi; John A. Crane; Xiang-Yang Zhu; Aditya S. Pawar; James D. Krier; Kyra L. Jordan; Hui Tang; Stephen C. Textor; Amir Lerman; Lilach O. Lerman; American Journal of Physiology-Renal Physiology 2013, 305, F265-F276. Copyright © 2013 American Physiological Society