Introduction Into Biochemistry

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Presentation transcript:

Introduction Into Biochemistry

What is Biochemistry? Biochemistry = chemistry of life. Biochemists use physical and chemical principles to explain biology at the molecular level. Basic principles of biochemistry are common to all living organism

How does biochemistry impact you? Medicine Agriculture Industrial applications Environmental applications

Principle Areas of Biochemistry Structure and function of biological macromolecules Metabolism – anabolic and catabolic processes. Molecular Genetics – How life is replicated. Regulation of protein synthesis

Origins of Biochemistry: A challenge to “Vitalism.” Famous Dead Biochemist!

Fallacy #1: Biochemicals can only be produced by living organisms 1828 Friedrich Wohler Dead Biochemist #1

Glucose + Dead Yeast = Alcohol Fallacy #2: Complex bioconversion of chemical substances require living matter Dead Biochemists #2 1897 Eduard Buchner Glucose + Dead Yeast = Alcohol

Fallacy #2: Complex bioconversion of chemical substances require living matter Dead Biochemists #3 Emil Fischer

Organization of Life elements simple organic compounds (monomers) macromolecules (polymers) supramolecular structures organelles cells tissues organisms

Range of the sizes of objects studies by Biochemist and Biologist 1 angstrom = 0.1 nm

Important compounds, functional groups

Many Important Biomolecules are Polymers lipids proteins carbo nucleic acids monomer polymer supramolecular structure

Lipids monomer polymer supramolecular structure

Proteins monomer polymer supramolecular structure amino acid Enzyme complex protein subunit amino acid

Carbohydrates monomer polymer supramolecular structure

Nucleic Acids monomer polymer supramolecular structure

Monomers form polymers through condensations Common theme: Monomers form polymers through condensations Polymers are broken down through hydrolysis.