Aroma & Flavor Chemistry Department National Research Center Nanotechnology & its Application in the delivery of Volatile Oils & Flavors Amr E. Edris Professor Aroma & Flavor Chemistry Department National Research Center Egypt

Used as targeted delivery systems 1- Medicine ~ 20 nm Used as targeted delivery systems for cancer treatment Solution of gold nano-particles

Silver Silver nano-particles (Anti-microbial activity) Wound dressing

2- Energy Silicon nano-particles Silver nano-particles Production of more efficient solar energy absorping cells

3- Nutrition Nanotechnology Enhances Bioavailability (5.0 % av.) Vitamin C 20.0% av. Curcumine 1.0% av. Nano-encapsulated Vit C (93.0% av.) Nano-encapsulated curcumine (5.0 % av.)

Can We Apply Nanotechnology in Fragrance & Flavors Industry ?

Yes: by formulating Environmental Friendly Fragrance 80 % organic solvent, 20 % volatile oil Ethanol Di-propylene glycol Diethyl phthalate

Environmental Protection Agency (EPA) calls for reduction of volatile organic compounds emission Using Organic Solvents

Global Fragrance Market (in billion U.S. dollars)* $51.0

Q: What shall Fragrance companies do ?? A: Replace organic solvent with water !! Volatile oil

Nanotechnology Can Help (Formulation of water-based nanoemulsions) + Water Surfactant High pressure valve homogenizer Water based fragrance (Organic Solvent Free)

(Organic Solvent Free) Water Based Fragrance (Organic Solvent Free) NANO Emulsion MACRO Emulsion Particle size 100 nm - 200 nm Particle size > 200 nm

Thermodynamically non stable During Storage in the Bottle NANO Emulsion MACRO Emulsion Thermodynamically non stable

Microemulsion Approach can solve this problem + Water Excess Surfactant No machine is needed Water based fragrance

Compare Appearance & Stability of these Water Based Fragrance Thermodynamically Stable (p.s. 1-100 nm) Thermodynamically non stable (p.s. 100-200 nm) Thermodynamically non stable (p.s. > 200 nm)

HOW ? What is the mechanism Water-hating group (Tail) Water-loving group (Head) Surfactant molecule

In water: surfactant take certain orientation “Self- assembly behavior” Aggregate (micelle) “nano-capsule” 2 nm - 10 nm Increase surfactant concentration

Titrate your fragrance oil !! Surfactant aggregates in water Shake Surfactant aggregates in water Water based fragrance (10 nm)

Environmental friendly fragrance (100% water-based) Demonstration: تجربة عملية للعرض Nano-encapsulation Microemulsion Tuberose Environmental friendly fragrance (100% water-based)

Nanotechnology in Using Volatile Oils in Personal Care Products Mouth Wash (against oral bacteria) 20 % Alcohol

(Microemulsion Approach) Now in the Market حاليا بالاسواق

Nanotechnology in Using Volatile Oils in Food Flavoring & Preservation Hoda S. El-Sayed, Remigius Chizzola, Asmaa A. Ramadan, Amr E. Edris A Food Chemistry (2017) 221; 196-204 B P.S.= 10.1 nm

Nanotechnology in using Volatile Oils as Antibiotics Hamdy A. Shaaban, Z. Sadek, A.E. Edris, and A. Saad-Hussein 0.2% 0.4% 0.6% 0.8% 1.0% Nigella sativa حبة البركة J. Oleo Science (2015) 64(2); 223-232 P.S.= 8.6 nm

Amr Edris amr_edris@hotmail.com Mobile: 010 127 151 30