Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary.

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Presentation transcript:

Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary disease Nicolas de Prost, MD, PhD, Claudine El-Karak, MD, Maria Avila, MD, Fumito Ichinose, MD, PhD, Marcos F. Vidal Melo, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 141, Issue 6, Pages 1496-1502.e3 (June 2011) DOI: 10.1016/j.jtcvs.2011.01.035 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Ratio of arterial Po2 (Pao2) to inspired oxygen fraction (Fio2; A) and airway resistances (Raw; B) of patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at 5 major interventional phases: before sternotomy (Baseline), before and after cardiopulmonary bypass (CPB), after chest closure (chest closed), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. Single asterisk indicates P < .05; double asterisk indicates P < .01; triple asterisk indicates P < .001. P values are derived from 2-way analysis of variance with repeated measurements, with Bonferroni adjustments for multiple comparisons. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Plasma (A) and urinary (B) cysteinyl leukotriene concentrations in patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9 for plasma and n = 8 for urine samples) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at 4 major interventional phases: before sternotomy (Baseline), at the end of cardiopulmonary bypass with continued extracorporeal circulation (End CPB), after cardiopulmonary bypass but before chest closure (After CPB), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. Single asterisk indicates P < .05; double asterisk indicates P < .01; triple asterisk indicates P < .001. P values are derived from 2-way analysis of variance with repeated measurements, with Bonferroni adjustments for multiple comparisons. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

White blood cell (A) and platelet (B) counts in patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at baseline before sternotomy (BL), after chest closure (CC), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. Double asterisk indicates P < .01; triple asterisk indicates P < .001. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Compliance of the respiratory system (Crs) in patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at 5 major interventional phases: before sternotomy (Baseline), before and after cardiopulmonary bypass (CPB), after chest closure (chest closed), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. Double asterisk indicates P < .01; triple asterisk indicates P < .001. P values are derived from 2-way analysis of variance with repeated measurements, with Bonferroni adjustments for multiple comparisons. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Plasma (A) and urinary (B) leukotriene B4 concentrations of patients with chronic obstructive pulmonary disease (COPD, filled circles, n = 9 for plasma and n = 8 for urine samples) and without chronic obstructive pulmonary disease (non-COPD, open circles, n = 10) at 4 major interventional phases: before sternotomy (Baseline), at the end of cardiopulmonary bypass with continued extracorporeal circulation (End CPB), after cardiopulmonary bypass but before chest closure (After CPB), and 2 hours after intensive care unit admission (ICU). Horizontal bars represent median values. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Cysteinyl leukotrienes (A) and leukotriene B4 (B) tracheal aspirate concentrations in 8 patients with COPD before sternotomy (Baseline) and after cardiopulmonary bypass (CPB). Horizontal bars represent median values. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 1496-1502.e3DOI: (10.1016/j.jtcvs.2011.01.035) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions