ReDVA mid-term review meeting Stratos Kokkalis Dundee 03/06/2015

Background BSc, MSc Biomedical Engineering PhD Biomedical Engineering (November 2014) University of Dundee Thesis: Fluid dynamic assessments of spiral flow induced by vascular grafts

ReDVA post July 2014 – October 2015 Work packages 4, 5 and 7 ESR seconded from the University of Dundee to Vascular Flow Technologies Stephen Broderick, Leonard Browne, Nicolas Aristokleous, Conor MacDonald, Craig Dunlop, Graeme Houston

ReDVA projects VFT R&D on spiral stent – CAD, flow testing, CFD VFT R&D on spiral catheters – CAD, flow testing, CFD VFT validation and verification of new grafts VFT flow rig Evaluation of VFT research historical data to update VFT regulatory records MRI based computational study on haemodialysis fistulas MRI study on the effect of arm position on vascular shape and haemodynamics

Computer aided design of VFT new vascular devices Spiral stents Spiral central venous catheters

Prototyping of VFT new vascular devices

Flow testing of VFT new vascular devices Flow phantoms Cadaveric models Animal models Phantom Animal Cadaver

VFT grafts validation and verification Validation and verification process in industry Quality regulations – European Medical Device Directive, US Food and Drug Administration, ISO 13485:2003 Product development – new grafts had to come closer to the optimum design Apply outcomes of my PhD in industry – flow phantoms, imaging, observations on spiral grafts

Other experience gained in VFT Writing qualification reports for industry Vascular devices commercialisation and marketing Understanding the difference between academic and industrial approach on problem solving and demands Computer skills – networks, CAD Medical devices regulatory processes

MRI studies knowledge gained so far Magnetic resonance imaging techniques Segmentation of MRI clinical data Extraction of vascular velocity waveforms MRI clinical protocol and ethics

MRI studies knowledge to be acquired Patient specific vascular CFD applications New meshing techniques CFD simulations with pulsatile flow waveforms Estimation of advanced WSS parameters

Conferences – courses International Congress of Vascular Access Society 2015 Flow phantoms and imaging – Edinburgh workshop 2015 Public engagement in Dundee Science Festival 2014 MRI conference Dundee 2014 Interventional radiology course 2014 Conference of the Vascular Access Society in Britain and Ireland 2014 Good clinical practice 2014 Great networking opportunities

Publications supported by ReDVA Haemodynamics and peripheral arterial stents, Annals of Biomedical Engineering Comparison of spiral and conventional arteriovenous grafts using computational methods, Congress of Vascular Access Society, 2015, Barcelona, Spain. Computational comparison of a spiral and a non-spiral peripheral bypass graft, World Congress of Biomechanics, July, 6-11, 2014, Boston, USA The effect of position on arterial and venous geometry in the arm: a single case observational study, Congress of Vascular Access Society, 2015, Barcelona, Spain Re-introducing spiral flow in a vascular access graft using a spiral inducing stent, American Society of Nephrology,2014 Philadelphia, USA Improving central vein blood flow parameters in central vein catheter dialysis, American Society of Nephrology, 2014, Philadelphia, USA Great networking opportunities