Myeloproliferative Neoplasm (MPN) Clinical Trials Portfolio Recruiting MPN Trials PHAZAR (Interventional) Accelerated or blast phase MPN PI: Prof Claire Harrison A Phase 1b Study to assess the safety and tolerability of oral Ruxolitinib in combination with Azacitidine in patients with Advanced Phase MPN, including MDS or AML arising from MPN Eligibility Criteria: -Age 16 and over, Diagnosis of ET,PV or MF with either bone marrow blasts (with or without dysplastic changes) or >20% bone marrow blasts, ECOG performance status:0-3. CAMBRIDGE (Observational) The Causes of Clonal Blood Cell Disorders Patients with clonal haematological disorders. MEASURES All MPN PI: Dr Deepti Radia The MPN Experimental Assessment of Symptoms by Utilizing Repetitive Evaluation (MEASURES) Trial: Serial Assessment of Symptomatic Response to Non Experimental Medical Therapies and/or Phlebotomy in Patients with Myeloproliferative Neoplasms -All MPN patients starting a new, therapeutic intervention. TAMARIN Effects of TAMoxifen on the Mutant Allele Burden and Disease Course in Patients with MyeloprolifeRatIve Neoplasms -PV,ET,MF stable disease on hydroxurea, bilirubin or ruxolutinib. No prior thrombosis. Age over 60, men aged between 50-59 may be considered, women must be post-menopausal. BLU-285-2101 Systemic mastocytosis A Phase 1 Study of BLU-285 in Patients with Advanced Systemic Mastocytosis (advSM) and Relapsed or Refractory Myeloid Malignancies -Age 18 over and have an ECOG performance status of 0-3. Part 1 of study: Patients with advSM or other relapsed or refractory myeloid malignancy. Part 2 of study: Patients are split into 3 groups-ASM,SM,AHNMD and MCL MPN Clot PVor ET PI Prof C Harrison Treatment of Polycythaemia Vera and Essential Thrombocythaemia: influence on the clot structure. Eligibility Criteria: -All men and women, older than 18 years, with a diagnosis of PV or ET (primary or secondary. INCYTE INCB 54828-203 Myeloid lymphoid disorders with 8p11 A Phase 2, Open-Label, Monotherapy, Multicenter Study to Evaluate the Efficacy and Safety of INCB054828 in Subjects With Myeloid/Lymphoid Neoplasms With FGFR1 Rearrangement Eligibility Criteria: Age 18 and over, lymphoid or myeloid neoplasm with 8p11 rearrangement known to lead to FGFR1 activation and subjects who are not candidates for stem cell transplantation but have progressed, will be eligible. Navitoclax (ABT-263) Myelofibrosis A Phase 2 Single-Arm, Open-Label Study Evaluating Tolerability and Efficacy of Navitoclax in Combination with Ruxolitinib in Subjects with Myelofibrosis. Eligibility Criteria: -Age 18 and over, diagnosis of primary MF,PPV_MF or PET_MF, ineligible or unwilling to undergo stem cell transplantation, Subjects must have received ruxolitinib therapy for at least 24 weeks and be on a stable dose of more than 10mg BID of ruxolitinib more than 8 weeks prior to 1st dose of navitoclax, ECOG of 0.1 or 2. MPN Trials in Set-up ACE-536 (Interventional) Myelofibrosis PI Prof C Harrison A Phase 2, Multicenter, Open-Label Study to Evaluate the Efficacy and Safety of Luspatercept (ACE-536) in Subjects with Myeloproliferative Neoplasm-Associated Myelofibrosis and Anemia with and without Red Blood Cell-Transfusion Dependence Eligibility Criteria: -Age 18 or over, subject has MPN-associated myelofibrosis, subject has anemia and an ECOG performance score ≤2. Includes patients currently on ruxolitinib, but may also not be on the drug PAC203 An Open-Label, Randomized, Phase 2 Dose-Finding Study of Pacritinib in Patients with Primary Myelofibrosis Previously Treated with Ruxolitinib Eligibility Criteria: -Diagnosed with PMF, prior ruxolitinib treatment failure, palpable splenomegaly of more than or equal to 5cm, peripheral blast count of less than 10%. INForMeD (Observational) An observational and biological research study to investigate the genetic and cellular basis of sporadic and familial myeloid disorders. Eligibility Criteria:- Age 2 or over, patients under investigation for or diagnosed with a myeloid or related disorder, patient willing to give consent to the study. DCC-2618-01-001 Invictus Systemic Mastocytosis PI: Dr Deepti Radia A multicentre Phase 1, Open-Label Study of DCC-2618 to assess safety, tolerability, efficacy and pharmacokinetics in patients with advanced malignancies. Eligibility criteria:- Age 18 or over, gastrointestinal stromal tumor patients must have KIT it PDGFRA mutation and must have progressed on or had intolerability to at least 1 but not more than 4 lines of systemic anticancer therapy, Systemic mastocytosis (SM patients) must have a confirmed diagnosis of advanced SM according to 2016 world health organisation (WHO) criteria for SM. Realism UK An observational study to collate retrospective real world evidence to review the current treatment pathways for Myelofibrosis from across the UK. Eligibility Criteria:- Age 18 and over, diagnosis of MF in the last 5 years, patient has consented to the study and has had at least 1 follow up visit following diagnosis of MF. Haematology Research contact details Professor Claire Harrison Email: claire.harrison@gstt.nhs.uk/ Tel: 0207 1882742 Dr Deepti Radia Email: deepti.radia@gstt.nhs.uk/ Tel: 0207-1883423 Dr Donal Mclornan Email: donal.mclornan@nhs.net General Enquiries HaematologyResearchTeam@gstt.nhs.uk