Immunopathogenesis of human gastrointestinal infection by Anisakis simplex Victoria del Pozo, PhDa, Ignacio Arrieta, MDa, Teresa Tuñon, MD, PhDb, Isabel.

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Presentation transcript:

Immunopathogenesis of human gastrointestinal infection by Anisakis simplex Victoria del Pozo, PhDa, Ignacio Arrieta, MDa, Teresa Tuñon, MD, PhDb, Isabel Cortegano, BSa, Belen Gomez, MDc, Blanca Cárdaba, PhDa, Soledad Gallardo, PhDa, Marta Rojo, BSa, Guadalupe Renedo, MD, PhDd, Pilar Palomino, PhDa, Ana I. Tabar, MD, PhDc, Carlos Lahoz, MD, PhDa Journal of Allergy and Clinical Immunology Volume 104, Issue 3, Pages 637-643 (September 1999) DOI: 10.1016/S0091-6749(99)70336-2 Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 1 A, Histologic section showing larva in the submucosal layer of intestine, with cellular infiltrate composed of eosinophils and lymphocytes, of a patient with anisakiasis (patient 13). B, Microscopic view of the parasite in the submucosa. Journal of Allergy and Clinical Immunology 1999 104, 637-643DOI: (10.1016/S0091-6749(99)70336-2) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 2 mRNA expression of cytokines, chemokines, iNOS, and MBP in intestinal biopsy specimens. A, Cytokine profile of mRNA for TH1 (IL-2 and IFN-γ) and TH2 (IL-4 and IL-5) cytokines in intestinal biopsy specimens from patients with EG caused by A simplex infestation. The presence of T cells was confirmed by T-cell receptor amplification. β-Actin was used to normalize RNA from tissues. B, Chemokines studied in tissue sections from patients with anisakiasis. IL-8 and eotaxin gene expression was studied by RT-PCR followed by Southern blot. C, Tissues positive for iNOS and MBP in the intestinal biopsy specimens of patients with EG detected by RT-PCR. Journal of Allergy and Clinical Immunology 1999 104, 637-643DOI: (10.1016/S0091-6749(99)70336-2) Copyright © 1999 Mosby, Inc. Terms and Conditions

Fig. 3 A, Proliferative response of lymphocytes from patients with anisakiasis and healthy control subjects. PBMCs were stimulated with different doses (5, 25, and 100 μg/mL) of A simplex and Ascaris extract. Data represent mean of stimulation indexes (SI) ± SD. The stimulation index was calculated by the ratio between the mean of disintegrations per minute from stimulated cells and the mean of disintegrations per minute from unstimulated cells from triplicate cultures. Control represents mean of stimulation index ± SD of 6 different healthy subjects. B, Cells were cultured with different doses (0, 5, 25, and 100 μg/mL) of Anisakis and Ascaris extracts. Supernatants were collected at different times (24 and 72 hours) to analyze IL-5 and IFN-γ levels. Data represents mean of 3 different patients (patients 8, 12, and 13). The values of IL-5 production are given in picograms per milliliter and correspond to 247 ± 23 pg/mL for the dose of 5 μg/mL A simplex , 357 ± 33.2 pg/mL for the dose of 25 μg/mL antigen, and 378 ± 36.9 pg/mL for the dose of 100 μg/mL. Journal of Allergy and Clinical Immunology 1999 104, 637-643DOI: (10.1016/S0091-6749(99)70336-2) Copyright © 1999 Mosby, Inc. Terms and Conditions