RBC membrane disorders

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MLAB 1415: Hematology Keri Brophy-Martinez

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Presentation transcript:

RBC membrane disorders RBC membrane disorders. The normal erythrocyte morphology is a biconcave disc, but RBC membrane defects cause an abnormal morphologic appearance among circulating erythrocytes, which leads to hemolytic anemia. A: Spherocytes that are small dense cells lacking central pallor. B: Elliptocytes that have an oval elongated shape. C: Spheroelliptocytosis featuring cells with features of both spherocytes and elliptocytes. D: Hereditary pyropoikilocytosis with bizarre morphology, including small triangular erythrocytes. Source: Chapter 433. Hemolytic Anemia, Rudolph's Pediatrics, 22e Citation: Rudolph CD, Rudolph AM, Lister GE, First LR, Gershon AA. Rudolph's Pediatrics, 22e; 2011 Available at: http://accesspediatrics.mhmedical.com/DownloadImage.aspx?image=/data/books/rudo22/rudo22_c433f002.jpg&sec=40337663&BookID=455&ChapterSecID=40310746&imagename= Accessed: December 28, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved