Gastrointestinal and liver diseases The predictive value of CRP / albumin ratio in acute pancreatitis Mustafa Kaplan1, Ihsan Ates2, Muhammed Yener Akpinar1, Mahmut Yuksel1, Ufuk Baris Kuzu1, Sabite Kacar1, Orhan Coskun1, Ertugrul Kayacetin1 1Turkey Yuksek Ihtisas Training and Research Hospital, Department of Gastroenterology, 06100, Ankara, Turkey 2Ankara Numune Training and Research Hospital, Department of Internal Medicine, 06100, Ankara, Turkey Gastrointestinal and liver diseases P.0394 Introduction Results In our study, the CRP/albumin ratio was found to be higher in exitus patients when compared to patients who survived and determined to be a prognostic factor increasing the risk of mortality. The CRP/albumin ratio was positively correlated with Ranson score, mortality score and Atlanta score in particular and with important prognostic markers such as hospitalization time, CRP and ESR. In addition to the CRP/albumin ratio, necrotizing pancreatitis type, 40% mortality score, moderately severe and severe Atlanta score, and total Ranson score were determined to be independent risk factors predicting mortality. It was found that an increase of 1 unit in the CRP/albumin ratio resulted in an increase of 1.371 times in mortality risk. A prediction value about CRP/albumin ratio>16.28 was found to be a significant marker in predicting mortality with 92.1% sensitivity and 58% specificity. It was seen that Ranson and Atlanta scores were higher in patients with CRP/albumin ratio ≥16.28 compared with patients who had CRP/albumin ratio < 16.28, those with CRP/albumin ratio ≥16.28 had a 19.271 times higher chance of death. Acute pancreatitis (AP) is a severe inflammation of the pancreas presented with sudden onset and severe abdominal pain and has high morbidity and mortality rate. In terms of etiology, it is mostly associated with gallstones and alcohol. Although its prognosis is not known for certain, it is associated with intra-acinar activation of proteolytic enzymes, leukocyte chemoattraction, release of cytokines, oxidative stress and microcirculatory injury. The common factor in all these mechanisms is an excessive inflammatory response Objectives In the present study, we investigated the predictive significance of the CRP/albumin ratio for the prognosis and mortality in acute pancreatitis patients. Conclusions The CRP/albumin ratio is a novel but promising, easy-to-measure, repeatable, non-invasive inflammation-based prognostic score in acute pancreatitis. References Methods This study was performed retrospectively with 192 acute pancreatitis patients between January 2012-June 2015. Ranson scores, Atlanta scores and CRP/albumin ratios of the patients were calculated by examining their patient files. 1. Steer ML. Pathogenesis of acute pancreatitis. Digestion 1997;58 Suppl 1:46-49. PMID:9225091. 2. Halangk W, Lerch MM, Brandt-Nedelev B, Roth W, Ruthenbuerger M, Reinheckel T, et al. Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis. J Clin Invest 2000;106:773-781. PMID:10995788. doi: 10.1172/JCI9411. 3. Prinz RA. Mechanisms of acute pancreatitis. Vascular etiology. Int J Pancreatol 1991;9:31-38. PMID:1744444.