Treatment algorithm for CIS and relapsing-remitting MS Treatment algorithm for CIS and relapsing-remitting MS.30 aA definition of aggressive multiple sclerosis has been proposed as follows: two or more relapses in the preceding year and two or more gadolinium-enhancing lesions on brain MRI scans or a significant T2 lesion burden.31 Source: Multiple Sclerosis, Pharmacotherapy Principles & Practice, 4e Citation: Chisholm-Burns MA, Schwinghammer TL, Wells BG, Malone PM, Kolesar JM, DiPiro JT. Pharmacotherapy Principles & Practice, 4e; 2016 Available at: https://ppp.mhmedical.com/DownloadImage.aspx?image=/data/books/1793/chis_ch30_f004.png&sec=120651720&BookID=1793&ChapterSecID=120651621&imagename= Accessed: December 28, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved