GUT PHYSIOLOGY Absorption 1 Dr. Jack Grider Rm Sanger Hall

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Presentation transcript:

GUT PHYSIOLOGY Absorption 1 Dr. Jack Grider Rm 12-004 Sanger Hall 828-1853 jgrider@vcu.edu 2009

Digestion & Absorption

Digestion & Absorption Brush Border

Digestion & Absorption Absorption from the lumen is impeded by the unstirred layer and the apical membrane of the enterocyte.

Digestion & Absorption Two routes of absorption Are available for movement of nutrient across the apical membrane of the enterocyte: - Paracellular Transcellular active & passive

Digestion & Absorption Transcellular route of absorption utilizes multiple mechanisms to bypass the membrane barrier.

Digestion; Carbohydrate Ingestion of large glucose polymers as starches and some sucrose (Glu-Fru) and lactose (Glu-Gal). Digestions occurs at level of Oral cavity: ptyalin Stomach Small intestine: pancreatic amylase Brush border

Digestion & Absorption: Carbohydrate

Digestion & Absorption: Carbohydrate

Digestion & Absorption: Carbohydrate GLUT5 SGLT1 GLUT2

Digestion & Absorption: Carbohydrate

Digestion: Protein Ingestion: long chains of amino acids as protein Endogenous: enzymes, mucus, dead cells Digestion: Stomach: Pepsin (low pH) Intestine: pancreatic peptidases brush border

Digestion & Absorption: Protein

Digestion & Absorption: Protein

Digestion & Absorption: Protein

Digestion & Absorption

Digestion & Absorption

Digestion & Absorption