Microfluidics Roadmap for the Life Sciences FlowMap Microfluidics Roadmap for the Life Sciences Thilo Brenner & Jens Ducrée - IMTEK MANCEF COMS Commercialization of Micro and Nano Systems September 8-11, 2003 The Krasnapolsky Hotel Amsterdam (NL) September 10, 2003 Jens Ducrée - IMTEK

Project Sponsored by EU Partners FP 5 – IST 15 months Funding: 170 k€ IMTEK (project leader) Wicht Technologie Consulting Cranfield Biotechnology Center HSG-IMIT Yole Développment      Jens Ducrée

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Biotech Life Sciences Markets Ecology Fields of Application Proteomics Cellomics Genomics Drug Delivery Lead Generation Biotech Therapeutics enabling Artificial Tissue Drug Discovery Lead Optimization Medicine Life Sciences Diagnostics Patient Monitoring Markets Compound Libraries Ecology Fields of Application Forensics Food Air Agriculture Water

µFluidic Technologies Flow Control Sensing Valving Pumping Techniques Flow Sensing Biosensitive Transduction Onchip Detection Pipetting & Dispensing Particle Counting Fabrication Technologies Well Plate Technology Particle Manipulation Liquid Handling Laden Fluids Particle- Concentration Separation Microarray Substrates Onchip Separation Arraying Microarrays Onchip Microreacting Onchip Micromixing Lab-on-a-Chip

Market Research Roadmap External Internal Market Studies Mailings EU Programs Personal Interviews Conferences Expert Workshops Expertise of Consortium Jens Ducrée

Background of Participants Jens Ducrée

Current Status of µFluidic Technologies Jens Ducrée

Advantages of Microfluidic Technologies Jens Ducrée

Technical Significance Jens Ducrée

Demands on µFluidic Technologies Jens Ducrée

Market Drivers Jens Ducrée

Hurdles for Commercial Success Jens Ducrée

Materials – Current Use Jens Ducrée

Materials – Future Use Jens Ducrée

µFluidic Technologies - Current Jens Ducrée

µFluidic Technologies - Future Jens Ducrée

Most Promising Markets for µFluidics Jens Ducrée

Market Estimate 2002 Jens Ducrée

Expected Market Growth Jens Ducrée

Market Estimate 2008 Conservative estimate D&MD estimate CAGR of 19% 50% growth 1600 M$ in 2006 Jens Ducrée

Dissemination www.microfluidics-roadmap.com Public report Distribution 100+ pages Fall 2003 Distribution CDROM Brochure www.microfluidics-roadmap.com Jens Ducrée

Contact Jens Ducrée IMTEK Lab for MEMS Applications University of Freiburg, Germany Phone: +49 / 761 / 203-7320 Email: ducree@imtek.de www.microfluidics-roadmap.com Jens Ducrée

Technological Environment Complemetary technologies Upstream technologies Materials Components Downstream: product / service concepts Technology under investigation Market demand and supply Product technology Production technology Competing systems (close substitution) Downstream systems based on alternative technologies (wider substitution) Other upstream technologies Jens Ducrée

external impact factors internal impact factors technology under investigation internal impact factors Economic development science standards & legistation market demand politics demography competition infrastructure social value system Jens Ducrée

Performance Envelope market drivers (pull) dimensions performance technology capabilities and constraints (push) performance envelope dimensions Jens Ducrée

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Inkjet Printing Printhead Ink Substrate Continuous On-Demand Porous (Paper, ...) Non-Porous (Plastic, Metal, ...) Ink Base Colorant Piezo Thermal

Printheads Jens Ducrée

Inkjet Ink Technology Jens Ducrée

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Industrial Automation Pneumatics Flow Control Sensors

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Industrial Dispensers Agro- / Food Technical Glue Solder Lubricants Flavors Scents Pheromones

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Chem. Process Engineering Micromixers Microdispersers Heat Exchangers Chemical Microreactors IMM

Markets for Microfluidics Markets for Microfluidics Life Sciences Markets for Microfluidics Printing Industrial Automation Industrial Dispensers Chem .Process Engineering Power Systems

Power Systems Fuel Cells Micro- Combustors Fuel Processors Fluidic Microthrusters Steam Reformers Partial Oxidation

Markets Product Groups Drug Discovery Lead Generation Lead Optimization Compund Libraries Markets Liquid Handling Microarrays Lab-on-a-Chip Liquid Handling Liquid Handling Product Groups Jens Ducrée

Markets Product Groups Medicine Diagnostics Markets Therapeutics Patient Monitoring Drug Delivery Artifical Tissue, Glands, Organs Forensics In-Vivo In-Vitro Diffusional Flow Microarrays Lab-on-a-Chip Lab-on-a-Chip Fabrication Flow Control ??? Lab-on-a-Chip Biochemical Sensors Microarrays Particle-Laden Fluids Biochemical Sensors Product Groups Jens Ducrée

Markets Product Groups Ecology Markets Agriculture Food Air Water Biochemical Sensors Biochemical Sensors Lab-on-a-Chip Biochemical Sensors Biochemical Sensors Lab-on-a-Chip Lab-on-a-Chip Microarrays Lab-on-a-Chip Lab-on-a-Chip Particle-Laden Fluids Particle-Laden Fluids Product Groups Jens Ducrée

Markets Product Groups Biotech Genomics Proteomics Cellomics Markets Microarrays Microarrays Lab-on-a-Chip Lab-on-a-Chip Lab-on-a-Chip Particle-Laden Fluids Flow Control Product Groups Jens Ducrée

µFluidic Technologies Product Groups Flow Control Biochemical Sensors Liquid Handling Microarrays Lab-on-a-Chip Particle-Laden Fluids Pumping Techniques Biosensitive Transduction Pipetting & Dispensing Arraying Onchip Micromixing Particle Concentrating Valving Well Plate Technology Microarray Substrates Onchip Microreacting Particle Manipulation Flow Sensing Onchip Separation Particle Counting Onchip Detection: Physical, Chemical, Electrical, Optical, … µFluidic Technologies Jens Ducrée

basic sciences applied sciences MEMS engineering Biochemistry Chemistry Physics Biology Medicine Micro- optics Hydro- dynamics Micro- actuators Mechanics MEMS Micro- electronics engineering Micro- sensors Computing / Bioinformatics

Technology Roadmapping Business / Market / Drivers purpose (know-why) Products / Services / Capabilities delivery (know-what) No Market Technologies / R&D Programs Knowledge / Resources STOP resources (know-how) time Jens Ducrée

Markets by Source of Sample Cell culture Cell extracts Synthesis Biotech Drug Discovery Medicine Ecology Compound library Synthesis Patient Blood Urine, … Nature Infrastructure Jens Ducrée

Opportunity vs Risk Jens Ducrée

Technology Roadmapping - Forecast Markets Products Technologies Jens Ducrée

Requested Improvements Jens Ducrée

Goal Microfluidics Life Sciences Microfluidics Life Sciences Technology drivers Business opportunities Microfluidics Life Sciences Market drivers Technological opportunities Jens Ducrée

Fabrication Technologies Materials Structuring Surface Modification Mass Fabrication Fabrication Technologies Sealing Prototyping Interfacing Integration