ROLE OF KINESIN & DYENIN Prepared and Presented By: Dr Laxmi Kant Pandey

Retrograde Movement Anterograde Movement

KINESIN (Mechanochemical enzyme) Kinesin is the motor protien. So far 14 classes of kinesin protien discovered

Structure of Kinesin I

Function of Kinesin

Mechanism KinesinI

Kye concepts Kinesin-I is a microtubule (+) end directed ATP- dependent motor that transports membrane-bound organells. Kinesin consists of two heavy chains, each with an N-terminal motor domain, and two light chains that associate with cargo. Kinesin superfamily includes motors that function in inetrphase and mitotic cells, transporting organelles and sliding antiparallel microtubules. The super family includes one class, Kinesis-13, that is not motile but destabilizes microtubule ends. Kinesin-I is a highly processive motor because it co ordinates ATP hydrolysis between its two heads so that one head is always firmly bound to a microtubule.

DYENIN Dynein is a motor protein in cells. Dynein transports various cellular cargo by "walking" along cytoskeletal microtubules towards the minus-end of the microtubule. This form of transport is known as retrograde transport.

1. Cytoplasmic dyneins and 2. Axonemal dyneins Classification Dyneins can be divided into two groups 1. Cytoplasmic dyneins and 2. Axonemal dyneins

References ‘Molecular Cell Biology’ by Harvey Lodish (Massachusetts Institute of Technology). ‘Student Companion for Molecular Cell Biology’ (3rd edition) by David Rintoul (Kansas State University).