From: Cold-Sensitive Corneal Afferents Respond to a Variety of Ocular Stimuli Central to Tear Production: Implications for Dry Eye Disease Invest. Ophthalmol.

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From: Cold-Sensitive Corneal Afferents Respond to a Variety of Ocular Stimuli Central to Tear Production: Implications for Dry Eye Disease Invest. Ophthalmol. Vis. Sci.. 2010;51(8):3969-3976. doi:10.1167/iovs.09-4744 Figure Legend: Sensitivity of cold-sensitive afferents to the hyperosmolar solutions. (a) Action potential discharges from a single neuron in response to vehicle and two different hyperosmolar solutions applied to the cornea (arrows above action potential traces). Numbers in parentheses are osmolarities of the solutions used to activate the neuron. (b) Average concentration-response functions of neurons to ocular application of NaCl and sucrose solutions. Normal saline (0.9%) was a vehicle solution for all concentrations of both NaCl and sucrose. NaCl (n = 16); sucrose (n = 9). Rmags to all hyperosmolar solutions were significantly different compared with vehicle (P < 0.01; one-way ANOVA). Date of download: 12/29/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.