Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients.

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Presentation transcript:

Accumulation of tissue advanced glycation end products correlated with glucose exposure dose and associated with cardiovascular morbidity in patients on peritoneal dialysis Jianping Jiang, Pingyan Chen, Jianghua Chen, Xueqing Yu, Di Xie, Changlin Mei, Fei Xiong, Wei Shi, Wei Zhou, Xusheng Liu, Shiren Sun, Ping Zhang, Xiao Yang, Yixiang Zhang, Yanmin Zhang, Xinling Liang, Zhimin Zhang, Qizhan Lin, Yan Yu, Toshio Miyata, Jianwei Tian, Min Liang, Weihong Luo, Xin Xu, Fanfan Hou Atherosclerosis Volume 224, Issue 1, Pages 187-194 (September 2012) DOI: 10.1016/j.atherosclerosis.2012.06.022 Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 Comparison of skin autofluorescence levels between PD and HD patients in each category of age (A) and dialysis duration (B) *P < 0.05 vs HD patients. Atherosclerosis 2012 224, 187-194DOI: (10.1016/j.atherosclerosis.2012.06.022) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Relationship between skin autofluorescence and glucose exposure dose in PD patients. A, elevated values of skin autofluorescence were strongly correlated with averaged glucose exposure dose per week in patients with or without diabetes. B, the skin autofluorescence values were correlated with total glucose exposure dose used during PD treatment. C, the average glucose exposure dose during PD increased with dialysis duration. Data were expressed as mean ± SD. ANOVA, P < 0.001. Atherosclerosis 2012 224, 187-194DOI: (10.1016/j.atherosclerosis.2012.06.022) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Comparison of cardiovascular morbidity between PD and HD patients in each category of age (A) and dialysis duration (B) *P < 0.05 in all. Atherosclerosis 2012 224, 187-194DOI: (10.1016/j.atherosclerosis.2012.06.022) Copyright © 2012 Elsevier Ireland Ltd Terms and Conditions