Volume 115, Issue 3, Pages 19S-23S (March 1999)

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Volume 115, Issue 3, Pages 19S-23S (March 1999) Pharmacodynamic Principles of Antimicrobial Therapy in the Prevention of Resistance Burgess David S. , Pharm D CHEST Volume 115, Issue 3, Pages 19S-23S (March 1999) DOI: 10.1378/chest.115.suppl_1.19S Copyright © 1999 The American College of Chest Physicians Terms and Conditions

Figure 1 Clinical pharmacology of antimicrobial therapy. CHEST 1999 115, 19S-23SDOI: (10.1378/chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

Figure 2 Relationship between the maximal peak plasma level to MIC ratio and the rate of clinical response in 236 patients with Gram-negative bacterial infection treated with aminoglycosides (gentamicin, tobramycin, or amikacin). Vertical bars represent SE values. From Moore et al,8 with permission. CHEST 1999 115, 19S-23SDOI: (10.1378/chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions

Figure 3 Pharmacodynamics of β-lactams: the relationship between the time above MIC against S pneumoniae (open symbols) and Haemophilus influenzae (closed symbols) and bacteriologic cure. From Craig and Andes,18 with permission. CHEST 1999 115, 19S-23SDOI: (10.1378/chest.115.suppl_1.19S) Copyright © 1999 The American College of Chest Physicians Terms and Conditions