Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography.

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Elevated Translocator Protein in Anterior Cingulate in Major Depression and a Role for Inflammation in Suicidal Thinking: A Positron Emission Tomography Study Sophie E. Holmes, Rainer Hinz, Silke Conen, Catherine J. Gregory, Julian C. Matthews, Jose M. Anton-Rodriguez, Alexander Gerhard, Peter S. Talbot Biological Psychiatry Volume 83, Issue 1, Pages 61-69 (January 2018) DOI: 10.1016/j.biopsych.2017.08.005 Copyright © 2017 Society of Biological Psychiatry Terms and Conditions

Figure 1 Regional mean [11C](R)-PK11195 binding potential (BPND) in patients with major depressive disorder (MDD) and control subjects, showing statistically significant elevations in the anterior cingulate cortex (ACC) but not in the prefrontal cortex (PFC) or insula. Asterisk (*) indicates significant at p < .05. Biological Psychiatry 2018 83, 61-69DOI: (10.1016/j.biopsych.2017.08.005) Copyright © 2017 Society of Biological Psychiatry Terms and Conditions

Figure 2 Regional [11C](R)-PK11195 binding potential (BPND) in controls, patients with major depressive disorder (MDD) with suicidal thoughts, and patients with MDD without suicidal thoughts. Horizontal bars indicate means. Open circles represent control subjects (n = 13), closed triangles represent patients with MDD with suicidal thoughts (n = 9), and closed circles represent patients with MDD without suicidal thoughts (n = 5). Asterisk (*) indicates significant at p < .05. ACC, anterior cingulate cortex; PFC, prefrontal cortex. Biological Psychiatry 2018 83, 61-69DOI: (10.1016/j.biopsych.2017.08.005) Copyright © 2017 Society of Biological Psychiatry Terms and Conditions