C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) or both? A systematic evaluation in pediatric ulcerative colitis  Dan Turner, David R. Mack, Jeffrey Hyams, Neal LeLeiko, Anthony Otley, James Markowitz, Yair Kasirer, Aleixo Muise, Cynthia H. Seow, Mark S. Silverberg, Wallace Crandall, Anne M. Griffiths  Journal of Crohn's and Colitis  Volume 5, Issue 5, Pages 423-429 (October 2011) DOI: 10.1016/j.crohns.2011.05.003 Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 1 Discriminant validity and best cutoff values to differentiate disease activity states of ESR (Fig. 1a) and C-reactive protein (Fig. 1b); both reflecting the combined derivation and validation cohorts. Disease activity states were defined by the PUCAI, as previously established.4 For simplicity, CRP values were truncated at 60mg/L and ESR at 120mm/h. Sens/Spec; sensitivity/specificity; AUROC; area under the ROC curve. Journal of Crohn's and Colitis 2011 5, 423-429DOI: (10.1016/j.crohns.2011.05.003) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 2 Summary ROC curve (SROC) of the different combination cutoffs of ESR and/or CRP (see text). Journal of Crohn's and Colitis 2011 5, 423-429DOI: (10.1016/j.crohns.2011.05.003) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions

Figure 3 Rate of normal ESR (i.e. <23mm/h) and normal CRP (<2.5mg/L) values, stratified by disease activity states (measured by the PUCAI). Journal of Crohn's and Colitis 2011 5, 423-429DOI: (10.1016/j.crohns.2011.05.003) Copyright © 2011 European Crohn's and Colitis Organisation Terms and Conditions