The Effects of PEEP on Oxygenation during One-Lung Ventilation

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Presentation transcript:

The Effects of PEEP on Oxygenation during One-Lung Ventilation Author n End Points Outcome Cohen E, et al J Cardiothorac Vasc Anesth 1996; 10:578-82 [ref 30] n=18 (prospective) Hypothesis pts with low PaO2 (<80 mmHg) during OLV may benefit from PEEP 10 cmH2O n=11 pts with PaO2 <80 mmHg FiO2 0.5% OLV PaO2 + PEEP (10) 65 ± 7 87 ± 32 Ren Y, et al Anaesth Intensive Care 2008; 36:544-48 [ref 35] n=30 OLV Best time Level of PEEP Group A – 0, 5, 10 cmH2O B – 5 cm H2O C – 10, 5, 0 cmH2O PaO2 lower w/o PEEP PaO2 better with 5 or 10 PEEP 10 cm H2O PEEP ↑Ppeak and Pplat Hoftman N, et al Ann Card Anaesth 2011; 14:183-187 [ref 36] n=41 OLV Efficacy of PEEP Preop predictors of response to PEEP OLV PEEP, 5 (15 min) PEEP, 10 (15 min) PEEP improved arterial oxygenation by ≥20% only 29% (n=12) Failure to improve oxygenation 71% Only VT 6.6 ml•kg among responders with PEEP