Structural features of the p53 gene and its encoded protein

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Structural features of the p53 gene and its encoded protein Structural features of the p53 gene and its encoded protein. The gene encodes a 53-kDa nuclear phosphoprotein. The 393 amino acids are spread over 11 exons. The transcription activation site (TAS), heat shock protein binding site (HSP), SV40 large T antigen binding sites (SV40), nuclear localization signal (NLS), oligomerization domain (OLIGO), and phosphorylation sites (P) all identify potential functional regions. The five evolutionarily conserved domains (HCD I-V) correspond closely to the regions most frequently mutated in sporadic cancer [hotspot regions (HSR A-D)]. Sites of binding of the extracellular E1B 55-kDa protein of adenovirus type 5 (E1B) and the E6 gene product of human papillomavirus types 16 and 18 (E6) are also indicated, as is the position of the MDM2 gene product-binding site (MDM2). Source: Li-Fraumeni Syndrome, The Online Metabolic and Molecular Bases of Inherited Disease Citation: Valle D, Beaudet AL, Vogelstein B, Kinzler KW, Antonarakis SE, Ballabio A, Gibson K, Mitchell G. The Online Metabolic and Molecular Bases of Inherited Disease; 2014 Available at: https://ommbid.mhmedical.com/DownloadImage.aspx?image=/data/books/971/ch37fg2.png&sec=62666704&BookID=971&ChapterSecID=62666677&imagename=&gboscontainerID=0 Accessed: December 30, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved