Allosteric Activators Jared Band Komal Vadodaria Lauren Castle Zeshan Kahn Period 4

Allosteric Regulation Specific molecules regulate enzyme activity in the cell The regulatory molecules change an enzyme’s shape Then, the regulatory molecules bind to another site on the molecule Result? The function of the active site changes (remember – each enzyme has a specific function provided by a specific “key and lock” to fit specific molecules) Via noncovalent bonds ALLOSTERIC REGULATION: a protein’s function is affected by a change in the binding of another molecule along another site

Definition Allosteric Activator: Specific molecules that adapt the shape of an enzyme in order to create more stability within the enzyme. These activators are unique to specific enzymes Each enzyme has a specific function Animated Diagram: http://course1.winona.edu/sberg/ANIMTNS/allostan.htm

So, allosteric activators make an enzyme more stable! So What? So, allosteric activators make an enzyme more stable! allows enzyme to perform specific function better

How does this relate to enzymes? Relating to Our Lives… Imagine that you have a Math test first period in the morning…. don’t eat breakfast = you do OK eat breakfast = do even BETTER food=energy  less distractions How does this relate to enzymes?

ATP hydrolysis: ADDING A WATER MOLECULE ATP binds to several catabolic enzymes allosterically  lowers their affinity for substrate and inhibits their activity while ADP acts as an activator of the same enzyme. If ATP production slows down, ADP accumulates and activates these key enzymes that speed up catabolism, producing more ATP. Catabolism slows down as ATP molecules accumulate and bind to enzymes, inhibiting them.

Video http://www.youtube.com/watch?v=M5bftq-W2aY