ELIXIR Safeguarding the results of life science research in Europe Niclas Jareborg

ELIXIR underpins life science research – across academia and industry ELIXIR connects national bioinformatics centres and EMBL-EBI into a sustainable European infrastructure for biological research data medicine agriculture bioindustries ELIXIR underpins life science research – across academia and industry environment www.elixir-europe.org

A distributed infrastructure to scale with the challenges ELIXIR infrastructure for Europe’s life science research sector ELIXIR Nodes build local bioinformatics capacity throughout Europe ELIXIR Nodes build on national strengths and priorities Biology has by far the largest research community: ~500,000 life science researchers in Europe >8 million web hits a day at EBI alone Creating a robust infrastructure for biological information is a bigger task than any individual organisation or nation can take on alone These are issues of such complexity that no single institution or country can tackle alone At the global level interactions with: RDA NIH BD2K GA4GH

ELIXIR Infrastructure Data Sustain core data resources Tools Services & connectors to drive access and exploitation Compute Access, Exchange & Compute on sensitive data Interoperability Integration and interoperability of data and services through standards. Training Professional skills for managing and exploiting data 5 platforms

ELIXIR-EXCELERATE

ELIXIR- ELIXIR prioritised by ESFRI in 2014 for implementation and operation support: €19 million 4 year project, 41 partners in 15 countries starts September 2015 Accelerate the implementation of ELIXIR across Nodes Develop and connect resources and services (from Nodes) Build bioinformatics capacity across Europe Five platforms: Data; Tools; Compute; Interoperability; Training Four Use Cases: Rare diseases; Human data; Plant genotype- phenotype; Marine metagenomics

EXCELERATE consortium 41 partners 15 countries

EXCELLERATE Structure

Resource management and governance principles of data and tools Data integration through a federated approach Scalable access and analysis of research data Role of communities developing around research data, computing and tools Actions to develop a culture of sharing and participation

EXCELERATE The success of ELIXIR service implementation is measured by and dependent on the advances reached in the scientific use cases and training. Use existing European e-Infrastructure resources to support the implementation of use cases and training. E.g. EGI federated cloud A particular challenge how to enable access, processing and transfer of human data. Working with Global Alliance for Genomics and Health (GA4GH) Framework for Responsible Sharing of Genomic and Health-Related Data

Thank you! Questions? Comments?

Human genomics data management

ELIXIR pilot with EGA archive 6. 2. EGA portal EGA dataset metadata 1. eduGAIN 3. SP REMS 5. SP 4. EGA Dataset delivery EGA datasets In the EGA AAI pilot REMS integrated to EGA service of EBI REMS creates workflows based on EGA metadata Next extending to new EGA Data access committees In the GEANT Enabling Users pilot, REMS and EGA login integrated to eduGAIN opened for R&E feds in CH, FI, IE, DE, IT, NL, FR Also studied EGA LoA requirements

ELIXIR AAI design (draft) Relying services EGA wiki … … … Cloud Intranet Data archive ELIXIR AAI Dataset authorisation management Credential translation ELIXIR Directory Group/role management ELIXIR Proxy IdP Bona fide management Attribute self-management External authentication (e-infrastructures) eduGAIN IdPs Common IdPs

ELIXIR identity Each user has one ELIXIR identity e.g. ”tommi@elixir-europe.org” ELIXIR Proxy maps external authentication providers to it e.g. nyronen@csc.fi (eduGAIN) e.g. tommioffinland@google (Google) e.g. 0000-0002-3634-3756 (ORCID) Also local username/password possible Relying services EGA wiki … … … Cloud Intranet Data archive ELIXIR AAI Dataset authorisation management Credential translation ELIXIR Directory Group/role management tommi@elixir-europe.org ELIXIR Proxy IdP Bona fide management Attribute self-management nyronen@csc.fi tommioffinland@google External authentication (e-infrastructures) eduGAIN IdPs Common IdPs

ELIXIR identity Relying services ELIXIR AAI EGA wiki … … … Cloud Intranet Data archive ELIXIR AAI tommi@elixir-europe.org (ELIXIR ID) External authentication (e-infrastructures) nyronen@csc.fi (eduGAIN) tommioffinland@google (Google ID) 0000-0002-3634-3756 (ORCID)

REMS – Resource Entitlement Management System Principal investigator Applicant Research group Members of the application Metadata on dataset 1&2 Dataset 1 Dataset 2 DAC 1 Approver DAC 2 Approver REMS Workflow Reports Entitlements IdP SP 1. Apply for access 4. Approve 5. Access 3. Circulate to approver 2. Commit to licence terms Software Federated authorisation Developed by ELIXIR-FI Open source available (LGPL) www.csc.fi/rems http://tnc2013.terena.org/getfile/870 Deployment Life sciences: EGA (ELIXIR), biobanks Linguistics (CLARIN-FI) Social science (CESSDA-FI) Other national Finnish services