NERVE MUSCLE PHYSIOLOGY

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Presentation transcript:

NERVE MUSCLE PHYSIOLOGY Dr Farzana Salman

OBJECTIVES At the end of this discussion you should be able to: 1. Know the structural components of a muscle fiber 2. Differentiate striated muscles & correlate it with structural components. 3. Know the major types & functions of Proteins present in a muscle fiber

Types of Muscles Skeletal. Excitability. . Structure Similarities Differences Skeletal. Excitability. . Structure Contractility . Location Cardiac. Elasticity. . Function Activation Smooth. . Contraction

Physiological anatomy of MUSCLE Muscle Fascicle

Physiological anatomy of MUSCLE

“Structural and functional Unit of the Muscle” S A R C O M E R E “Structural and functional Unit of the Muscle” Mainly Comprised of: Actin Filaments Arranged between two Z lines Myosin Filaments Besides these ?

SARCOPLASM Spaces between the myofibrils are filled with intracellular fluid called sarcoplasm. Potassium Magnesium Phosphate Protein enzymes Mitochondria

Sarcomere (Supportive Proteins) 1. Titin, 2. Actinin, 3. Desmin & 4. Dystrophin-Glycoprotein complex

SARCOMERE Proteins Titin: MW= 3 million Largest springy protein Provides scaffolding for the sarcomere Connects Z line to M line Actinin : MW=190,000 Binds actin to Z line Desmin: Binds Z line to plasma membrane

Dystrophin-Glycoprotein Complex Large Protein, MW = 427000 Forms a Rod which connects the Actin filament to the transmembrane Protein Beta-Dystroglycan in the sarcolema. Function: Adds strength to the muscle by providing a Scaffolding for the fibrils & connecting them to the Extra cellular Matrix

Dystrophin-Glycoprotein Complex Merosin

CLINICAL SIGNIFICANCE Muscular dystrophies. Diseases that cause progressive weakness of skeletal muscle 1) Duchenne muscular dystrophy. 2) Becker muscular dystrophy.

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