Volume 145, Issue 4, Pages 730-739 (October 2013) Central Obesity in Asymptomatic Volunteers Is Associated With Increased Intrasphincteric Acid Reflux and Lengthening of the Cardiac Mucosa  Elaine V. Robertson, Mohammad H. Derakhshan, Angela A. Wirz, Yeong Yeh Lee, John Paul Seenan, Stuart A. Ballantyne, Scott L. Hanvey, Andrew W. Kelman, James J. Going, Kenneth E.L. McColl  Gastroenterology  Volume 145, Issue 4, Pages 730-739 (October 2013) DOI: 10.1053/j.gastro.2013.06.038 Copyright © 2013 AGA Institute Terms and Conditions

Figure 1 Sample biopsy specimen across the gastroesophageal junction incorporating squamous, cardiac, and cardio-oxyntic mucosa. Gastroenterology 2013 145, 730-739DOI: (10.1053/j.gastro.2013.06.038) Copyright © 2013 AGA Institute Terms and Conditions

Figure 2 Inflammation and mucosal stress (reactive atypia) at the squamocolumnar junction compared with gastric body and antral mucosae. PMN, polymorphonuclear cell; MN, mononuclear cell; RA, reactive atypia. All comparisons are between scores of cardia and other locations, and tested by the Wilcoxon signed-rank test. Gastroenterology 2013 145, 730-739DOI: (10.1053/j.gastro.2013.06.038) Copyright © 2013 AGA Institute Terms and Conditions

Figure 3 Alterations in the gastrointestinal junction associated with increased waist circumference. The position of the SCJ is indicated by a broken line. The high-pressure zone of the LES is represented by the 2 vertical shaded columns and the position of the peak LES pressure by the facing apexes of the shaded triangles. ACID, gastric acidity is represented by the shaded area. The significance values for the position of the SCJ and pH transition point are relative to upper-border LES. Data are based on median postprandial supine values. Gastroenterology 2013 145, 730-739DOI: (10.1053/j.gastro.2013.06.038) Copyright © 2013 AGA Institute Terms and Conditions