Longevity, size, and insulin-like growth factor 1 (IGF-1) levels among breeds of purebred dogs. Left panel (A) shows mean breed lifespan as a function.

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Longevity, size, and insulin-like growth factor 1 (IGF-1) levels among breeds of purebred dogs. Left panel (A) shows mean breed lifespan as a function of mean breed weight for each of 16 breeds of dogs; three breeds are indicated by arrows. (Data from Li Y, Deeb B, Pendergrass W, Wolf N. Cellular proliferative capacity and life span in small and large dogs. J Gerontol A Biol Sci Med Sci. 1996;51(6):B403–B408.) Right panel (B) shows mean plasma IGF-1 levels as a function of body mass in eight breeds of purebred dogs. (For details and citations, see Miller RA, Austad SN. Growth and aging: why do big dogs die young? In: Masoro EJ, Austad, SN, eds. Handbook of the Biology of Aging, 6th ed., New York, NY: Academic Press; 2006.) Source: Biology of Aging and Longevity, Hazzard's Geriatric Medicine and Gerontology, 7e Citation: Halter JB, Ouslander JG, Studenski S, High KP, Asthana S, Supiano MA, Ritchie C. Hazzard's Geriatric Medicine and Gerontology, 7e; 2017 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/1923/haz7e_ch1_f008b.png&sec=144516758&BookID=1923&ChapterSecID=144516694&imagename= Accessed: December 31, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved

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