Pyridine piperidine alkaloids

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Presentation transcript:

Pyridine piperidine alkaloids

Pyridine alkaloids and Nicotinic acid derivatives: Biosynthetic origin: 1)- Nicotine: very toxic compound -Botanical source: leaves Nicotiana tobacum Solanaceae -Pharmacological effect: -It works on nicotinic receptor (start by stimulation then inhibition. -Highly hydrophobic, so can cross blood brain barrier. Uses as: Vehicle on CNS (stimulant), dental carries, Alzheimer ???? It's liquid compound, yellowish. Oxidized by light and will form brown color. Toxicity: Cancer which give nitrous amine (very nuclephilic) lead to change in DNA structure, Pulmonary and cardiac disease, Effect in hepatic system lead to increase metabolite .

Nicotine

Piperdine Alkaloid : (Lobelia). Biosynthetic origin: Botanical sours form Lobelia inflata Lobeliaece. Pharmacological effect: CNS Stimulant (cholinergic agonist). Uses: For premature babies (has Problem in respiration) so give cortisone to dilution lung. High dose cause tonic spasm for skeletal and smooth muscle.

Lobeline

Arecoline Alkaloid : Botanical sours are seed of Areca catechu Arecaceae. Pharmacological action: Parasympathomimetic work on messianic receptor and in high dose work on nicotinic receptor Uses:, Alzheimer disease, has Psychocyco active effect “Cigarette as cocaine in malaise”. It causes redness of mouth, teeth an saliva, when use for long time cause buccal cancer.

Arecoline