Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient - DOI:10.1159/000481851 Fig. 1. Renal.

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Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient - DOI:10.1159/000481851 Fig. 1. Renal biopsy results. a Specimen shows minimal change glomerulonephritis and acute tubule-interstitial nephritis. Glomeruli are intact but show reactive and edematous changes of the parietal and visceral epithelial cells. There is significant interstitial edema, acute tubular injury with associated mild interstitial nephritis, and exaggerated “minimal change” nephrosis. b The second renal biopsy shows progression (worsening) of the interstitial inflammation, edema, and glomerular epithelial changes. c Electron microscope shows podocyte effacement with no electron-dense deposits. © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC 4.0

Minimal Change Disease as Initial Presentation of ALK-Positive Anaplastic Large-Cell Lymphoma in a Pediatric Patient - DOI:10.1159/000481851 Fig. 2. Imaging studies showing marked lymphadenopathy. a Gallium scan shows intense gallium uptake along the left iliacus muscle extending linearly back up along the psoas and through the retroperitoneum (red arrow). b MRI of the pelvis shows a large, heterogeneously enhancing lymph node conglomerate extending from the left para-aortic region through the iliac chain into the left inguinal region. The left external iliac lymph node measures 3.8 × 2.2 cm in maximum anterior-posterior and transverse dimensions impressing upon the left lateral bladder wall (orange arrow). © 2017 The Author(s). Published by S. Karger AG, Basel - CC BY-NC 4.0