HLA Linkage vs Association in Hypertrophic Cardiomyopathy

Slides:

Advertisements

Similar presentations

Group A Beta Hemolytic Streptococci and Rheumatic Fever in Miami, Florida: I. Bacteriologic Observations from October 1954 through May 1955 MILTON S.

Advertisements

Volume 32, Issue 1, Pages (July 1957)

Tell-tale Telangiectasias

Colloquium on Therapy of Right Heart Failure

Volume 105, Issue 4, Pages (April 1994)

An Unusual Cause of Stridor and Progressive Shortness of Breath

When to Be Rash About a Fever and Headache

Right-Sided Chest Pain with Progressive Dyspnea

Volume 102, Issue 3, Pages (September 1992)

Antanas G. Razma, M. D. , F. C. C. P. , Joseph P. Lynch, M. D. , F. C

Volume 133, Issue 4, Pages (April 2008)

Hyperbaric Oxygenation in Cardiac and Pulmonary Disease

Air Pollution and Chest Disease

Rheumatic Heart Disease in East Pakistan

Navin K. Jain, MD, Thiam H. Lie, MD, FCCP CHEST

Volume 105, Issue 5, Pages (May 1994)

Clinical and Personality Profiles and Survival in Patients With COPD

Respiratory Nitric Oxide Levels in Experimental Human Influenza

Volume 113, Issue 4, Pages (April 1998)

Frank W. Ewald, MD, FCCP, Albert H. Scherff, MD CHEST

The Lung Cancer Stage Page

COUNTERPOINT: Is the Apnea-Hypopnea Index the Best Way to Quantify the Severity of Sleep-Disordered Breathing? No Naresh M. Punjabi, MD, PhD, FCCP CHEST

Volume 124, Issue 6, Pages (December 2003)

Spread the Word About CHEST in 2018

Has the 6-Min Walk Distance Run Its Course?

Posthyperventilation Apnea Associated with Severe Hypoxemia

Nonobstructive Hypertrophic Cardiomyopathy Out of the Shadows: Known from the Beginning but Largely Ignored … Until Now Barry J. Maron, MD, Ethan J.

Counterpoint: Adherence to Early Goal-Directed Therapy

Airway Stenting for Patients With Benign Airway Disease and the Food and Drug Administration Advisory Lund Mark E. , MD, FCCP, Force Seth , MD, FCCP

Apnea in the Nonobese CHEST Volume 153, Issue 4, (April 2018)

Decortication after 35 Years

Tako-Tsubo Cardiomyopathy: Response

Sleep Apnea, Hypothyroidism and Pulmonary Edema

Volume 152, Issue 4, Pages (October 2017)

PEEP, Auto-PEEP, and Waterfalls

Sundeep Salvi, MD, DNB, PhD, FCCP, Peter J. Barnes, DM, FCCP CHEST

Counterpoint: Should All ICU Patients Receive Continuous Sedation? No

Evaluation of Serum Theophylline Measurement using a Test-strip

Volume 104, Issue 1, Pages 1-2 (July 1993)

Raymond R. Tubbs, D.O., Sanford P. Benjamin, M.D. CHEST

New CHEST Associate Editors Named

Robert M. Hoffman, MD, Ronald A. Stiller, MD, PhD, FCCP CHEST

Imaging for the Management of Community-Acquired Pneumonia

Point: Should We Abandon FEV1/FVC <0

Spread the Word About CHEST in 2015

Brahms' Lullaby Revisited

Tako-Tsubo Cardiomyopathy: Response

Volume 138, Issue 4, Pages (October 2010)

Volume 103, Issue 6, Pages (June 1993)

Chemical Pneumonitis Due to Exposure to Bromine Compounds

GI Symptoms in Patients With COPD

Evolution in Reimbursement for Sleep Studies and Sleep Centers

Bedside Calibration Of Pulmonary Artery Catheters

Joseph A. Dearani, MD, Michael J. Ackerman, MD, PhD

Invasive Pulmonary Aspergillosis

Pulmonary Manifestations in a Case of Multiple Myeloma

Peter J.F.M. Merkus, MD, PhD, H.A.W.M. Tiddens, MD CHEST

Effects of Beta-Adrenergic Agents on Hypokalemia

A Single Nasal Prong for Continuous Oxygen Therapy

Myocardial Sarcoidosis Unresponsive to Steroids

Nasal Airflow in Sleep-Disordered Breathing

Volume 42, Issue 2, Pages (August 1962)

Calcification of the Coronary Artery

John M. Yackee, M.D., Reed M. Shnider, M.D., Alan G. Wasserman, M.D.

Digitalis and Angina Pectoris

Volume 133, Issue 4, Pages (April 2008)

Hypertrophic Cardiomyopathy

New Members of the Editorial Board

Rebuttal From Dr Kollef

John Reid, MD, Donald Cockcroft, MD CHEST

Presentation transcript:

HLA Linkage vs Association in Hypertrophic Cardiomyopathy Julius M. Gardin, M.D., F.C.C.P., John S. Gottdiener, M.D., Ruta Radvany, Ph.D., Barry J. Maron, M.D., Michael Lesch, M.D. CHEST Volume 81, Issue 4, Pages 466-472 (April 1982) DOI: 10.1378/chest.81.4.466 Copyright © 1982 The American College of Chest Physicians Terms and Conditions

Figure 1 Short arms of a pair of sixth chromosomes, showing loci (A, B, C, D, and DR) and allele variants known to occupy HLA region. CHEST 1982 81, 466-472DOI: (10.1378/chest.81.4.466) Copyright © 1982 The American College of Chest Physicians Terms and Conditions

Figure 2 Percent frequencies of B12 and AW32 antigens in control group of 503 North American Caucasians, in total group of 50 hypertrophic cardiomyopathy patients, and in hemodynamic obstructive, provocable, and nonobstructive subgroups. N = number of patients or subjects in each group; P values are uncorrected and represent comparisons to control group. CHEST 1982 81, 466-472DOI: (10.1378/chest.81.4.466) Copyright © 1982 The American College of Chest Physicians Terms and Conditions

Figure 3 Three hypothetical modes of association between hypertrophic cardiomyopathy and specific HLA antigen(s): J, Hypertrophic cardiomyopathy (HCM) susceptibility gene (°) is linked to a particular HLA allele, Bx. Population studies of the nth generation of all ethnic and racial groups would show an association between hypertrophic cardiomyopathy and antigen Bx (eg, HLA-B12). II, HCM susceptibility gene (*) is linked to different HLA alleles in various ethnic groups. Population studies of the nth generation would show an association with Bx in one ethnic group and Bz in another (eg, affected individuals of two distinct groups might type as HLA-B12 and HLA-B5 complex, respectively). III, HCM susceptibility gene (*) is linked to the HLA region—ie, gene is on sixth chromosome in close proximity to HLA region. As a result, an association with HLA would not be observed in population studies, but affected individuals of a given family would carry a particular HLA haplotype (eg, AvBx in one family and AyBz in another). CHEST 1982 81, 466-472DOI: (10.1378/chest.81.4.466) Copyright © 1982 The American College of Chest Physicians Terms and Conditions